STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CARD8Uncharacterized protein. (534 aa)    
Predicted Functional Partners:
NLRP3
NLR family pyrin domain containing 3.
 
 
 0.908
LOC484411
FIIND domain-containing protein.
  
  
 
0.901
DPP9
Dipeptidyl peptidase 9; Belongs to the peptidase S9B family.
    
 
 0.667
APAF1
Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase 9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).
    
 
 0.609
NLRP5
NLR family pyrin domain containing 5.
 
  
 
 0.581
DPP8
Dipeptidyl peptidase 8; Belongs to the peptidase S9B family.
    
 
 0.506
GSDMD
Gasdermin D.
    
 
 0.502
NLRP12
Uncharacterized protein.
 
 
 
 0.467
MEFV
MEFV innate immuity regulator, pyrin.
    
 
 0.464
BIRC6
Baculoviral IAP repeat containing 6.
   
 
 0.457
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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