STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CFBUncharacterized protein; Belongs to the peptidase S1 family. (823 aa)    
Predicted Functional Partners:
C3
Complement C3.
   
 0.975
CFH
Uncharacterized protein.
   
0.910
CFI
Complement factor I; Belongs to the peptidase S1 family.
   
 
 0.886
GZMK
Granzyme K; Belongs to the peptidase S1 family.
   
 
 0.857
LOC481722
Uncharacterized protein.
   
 0.842
CFP
Complement factor properdin.
   
 
 0.837
DGKE
Diacylglycerol kinase.
      
 0.745
THBD
Thrombomodulin; Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated (By similarity).
   
 
 0.704
LOC609365
Uncharacterized protein.
   
 0.692
C5
Complement C5.
   
 0.687
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.