node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCL2L1 | BRAF | ENSCAFP00000010478 | ENSCAFP00000005841 | BCL2 like 1. | B-Raf proto-oncogene, serine/threonine kinase. | 0.462 |
BCL2L1 | EGFR | ENSCAFP00000010478 | ENSCAFP00000005164 | BCL2 like 1. | Receptor protein-tyrosine kinase. | 0.549 |
BCL2L1 | ERBB2 | ENSCAFP00000010478 | ENSCAFP00000024079 | BCL2 like 1. | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | 0.405 |
BCL2L1 | KRAS | ENSCAFP00000010478 | ENSCAFP00000064230 | BCL2 like 1. | KRAS proto-oncogene, GTPase. | 0.931 |
BCL2L1 | TP53 | ENSCAFP00000010478 | ENSCAFP00000064590 | BCL2 like 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.993 |
BRAF | BCL2L1 | ENSCAFP00000005841 | ENSCAFP00000010478 | B-Raf proto-oncogene, serine/threonine kinase. | BCL2 like 1. | 0.462 |
BRAF | EGFR | ENSCAFP00000005841 | ENSCAFP00000005164 | B-Raf proto-oncogene, serine/threonine kinase. | Receptor protein-tyrosine kinase. | 0.601 |
BRAF | ERBB2 | ENSCAFP00000005841 | ENSCAFP00000024079 | B-Raf proto-oncogene, serine/threonine kinase. | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | 0.443 |
BRAF | KRAS | ENSCAFP00000005841 | ENSCAFP00000064230 | B-Raf proto-oncogene, serine/threonine kinase. | KRAS proto-oncogene, GTPase. | 0.973 |
BRAF | NF1 | ENSCAFP00000005841 | ENSCAFP00000035952 | B-Raf proto-oncogene, serine/threonine kinase. | Neurofibromin 1. | 0.825 |
BRAF | PIK3CA | ENSCAFP00000005841 | ENSCAFP00000048355 | B-Raf proto-oncogene, serine/threonine kinase. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.847 |
BRAF | RAF1 | ENSCAFP00000005841 | ENSCAFP00000007376 | B-Raf proto-oncogene, serine/threonine kinase. | Raf-1 proto-oncogene, serine/threonine kinase. | 0.939 |
BRAF | RALGDS | ENSCAFP00000005841 | ENSCAFP00000057240 | B-Raf proto-oncogene, serine/threonine kinase. | Uncharacterized protein. | 0.407 |
BRAF | SPRED1 | ENSCAFP00000005841 | ENSCAFP00000047550 | B-Raf proto-oncogene, serine/threonine kinase. | Sprouty related EVH1 domain containing 1. | 0.515 |
BRAF | TP53 | ENSCAFP00000005841 | ENSCAFP00000064590 | B-Raf proto-oncogene, serine/threonine kinase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.819 |
EGFR | BCL2L1 | ENSCAFP00000005164 | ENSCAFP00000010478 | Receptor protein-tyrosine kinase. | BCL2 like 1. | 0.549 |
EGFR | BRAF | ENSCAFP00000005164 | ENSCAFP00000005841 | Receptor protein-tyrosine kinase. | B-Raf proto-oncogene, serine/threonine kinase. | 0.601 |
EGFR | ERBB2 | ENSCAFP00000005164 | ENSCAFP00000024079 | Receptor protein-tyrosine kinase. | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | 0.997 |
EGFR | KRAS | ENSCAFP00000005164 | ENSCAFP00000064230 | Receptor protein-tyrosine kinase. | KRAS proto-oncogene, GTPase. | 0.935 |
EGFR | NF1 | ENSCAFP00000005164 | ENSCAFP00000035952 | Receptor protein-tyrosine kinase. | Neurofibromin 1. | 0.670 |