TNPO1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TNPO1

Transportin 1. (855 aa)

Predicted Functional Partners:

RAN

0.985

LOC100686305

0.976

FUS

0.947

ZFP36

0.901

IPO7

0.900

HNRNPM

0.883

NUP214

0.870

KIF17

0.842

BAP1

0.819

IPO4

0.793

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAP1	TNPO1	ENSCAFP00000031121	ENSCAFP00000011990	Ubiquitin carboxyl-terminal hydrolase.	Transportin 1.	0.819
FUS	HNRNPM	ENSCAFP00000024800	ENSCAFP00000063585	FUS RNA binding protein.	Heterogeneous nuclear ribonucleoprotein M.	0.629
FUS	TNPO1	ENSCAFP00000024800	ENSCAFP00000011990	FUS RNA binding protein.	Transportin 1.	0.947
HNRNPM	FUS	ENSCAFP00000063585	ENSCAFP00000024800	Heterogeneous nuclear ribonucleoprotein M.	FUS RNA binding protein.	0.629
HNRNPM	TNPO1	ENSCAFP00000063585	ENSCAFP00000011990	Heterogeneous nuclear ribonucleoprotein M.	Transportin 1.	0.883
IPO4	IPO7	ENSCAFP00000017742	ENSCAFP00000010873	Importin 4.	Importin 7.	0.859
IPO4	LOC100686305	ENSCAFP00000017742	ENSCAFP00000048537	Importin 4.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.700
IPO4	RAN	ENSCAFP00000017742	ENSCAFP00000009963	Importin 4.	GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...]	0.704
IPO4	TNPO1	ENSCAFP00000017742	ENSCAFP00000011990	Importin 4.	Transportin 1.	0.793
IPO7	IPO4	ENSCAFP00000010873	ENSCAFP00000017742	Importin 7.	Importin 4.	0.859
IPO7	LOC100686305	ENSCAFP00000010873	ENSCAFP00000048537	Importin 7.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.491
IPO7	NUP214	ENSCAFP00000010873	ENSCAFP00000029512	Importin 7.	Nucleoporin 214.	0.595
IPO7	RAN	ENSCAFP00000010873	ENSCAFP00000009963	Importin 7.	GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...]	0.614
IPO7	TNPO1	ENSCAFP00000010873	ENSCAFP00000011990	Importin 7.	Transportin 1.	0.900
KIF17	TNPO1	ENSCAFP00000064919	ENSCAFP00000011990	Kinesin family member 17; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Transportin 1.	0.842
LOC100686305	IPO4	ENSCAFP00000048537	ENSCAFP00000017742	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	Importin 4.	0.700
LOC100686305	IPO7	ENSCAFP00000048537	ENSCAFP00000010873	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	Importin 7.	0.491
LOC100686305	NUP214	ENSCAFP00000048537	ENSCAFP00000029512	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	Nucleoporin 214.	0.788
LOC100686305	RAN	ENSCAFP00000048537	ENSCAFP00000009963	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...]	0.900
LOC100686305	TNPO1	ENSCAFP00000048537	ENSCAFP00000011990	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	Transportin 1.	0.976