STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (491 aa)    
Predicted Functional Partners:
CASP8
Caspase 8; Belongs to the peptidase C14A family.
   
0.991
ITCH
E3 ubiquitin-protein ligase.
   
 0.965
ATG3
Autophagy-related protein 3.
   
 0.942
FAS
Fas cell surface death receptor.
   
 
 0.746
TNFSF10
Tumor necrosis factor ligand superfamily member.
   
 
 0.746
RIPK1
Receptor interacting serine/threonine kinase 1.
   
 
 0.741
TRADD
TNFRSF1A associated via death domain.
   
 
 0.710
APAF1
Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase 9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).
   
 
 0.675
DFFB
DNA fragmentation factor subunit beta.
    
 
 0.644
BIRC2
Baculoviral IAP repeat containing 2.
   
 
 0.604
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: medium (60%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.