node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCK | GAL | ENSCAFP00000065716 | ENSCAFP00000015855 | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume. | Galanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion; Belongs to the galanin family. | 0.923 |
CCK | GHSR | ENSCAFP00000065716 | ENSCAFP00000022639 | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume. | Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. | 0.537 |
CCK | INS | ENSCAFP00000065716 | ENSCAFP00000051648 | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.846 |
CCK | NPY | ENSCAFP00000065716 | ENSCAFP00000004135 | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume. | Neuropeptide Y. | 0.880 |
CCK | PPY | ENSCAFP00000065716 | ENSCAFP00000021236 | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume. | Pancreatic icosapeptide; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. | 0.884 |
CCK | SST | ENSCAFP00000065716 | ENSCAFP00000064277 | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume. | Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. | 0.965 |
CCK | SSTR2 | ENSCAFP00000065716 | ENSCAFP00000006717 | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume. | Somatostatin receptor type 2; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 [...] | 0.432 |
DRD2 | NPY | ENSCAFP00000020466 | ENSCAFP00000004135 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | Neuropeptide Y. | 0.948 |
DRD2 | PPY | ENSCAFP00000020466 | ENSCAFP00000021236 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | Pancreatic icosapeptide; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. | 0.449 |
DRD2 | SST | ENSCAFP00000020466 | ENSCAFP00000064277 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. | 0.947 |
GAL | CCK | ENSCAFP00000015855 | ENSCAFP00000065716 | Galanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion; Belongs to the galanin family. | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume. | 0.923 |
GAL | INS | ENSCAFP00000015855 | ENSCAFP00000051648 | Galanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion; Belongs to the galanin family. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.579 |
GAL | NPY | ENSCAFP00000015855 | ENSCAFP00000004135 | Galanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion; Belongs to the galanin family. | Neuropeptide Y. | 0.921 |
GAL | PPY | ENSCAFP00000015855 | ENSCAFP00000021236 | Galanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion; Belongs to the galanin family. | Pancreatic icosapeptide; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. | 0.529 |
GAL | SST | ENSCAFP00000015855 | ENSCAFP00000064277 | Galanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion; Belongs to the galanin family. | Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. | 0.943 |
GAL | SSTR1 | ENSCAFP00000015855 | ENSCAFP00000020273 | Galanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion; Belongs to the galanin family. | Somatostatin receptor type 1; Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins (By similarity). | 0.663 |
GAL | SSTR2 | ENSCAFP00000015855 | ENSCAFP00000006717 | Galanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion; Belongs to the galanin family. | Somatostatin receptor type 2; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 [...] | 0.667 |
GAL | SSTR3 | ENSCAFP00000015855 | ENSCAFP00000037746 | Galanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion; Belongs to the galanin family. | Somatostatin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family. | 0.597 |
GHSR | CCK | ENSCAFP00000022639 | ENSCAFP00000065716 | Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume. | 0.537 |
GHSR | INS | ENSCAFP00000022639 | ENSCAFP00000051648 | Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.417 |