node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNA1 | CCNA2 | ENSCAFP00000009291 | ENSCAFP00000006129 | Cyclin A1; Belongs to the cyclin family. | Cyclin A2; Belongs to the cyclin family. | 0.954 |
CCNA1 | FBXO5 | ENSCAFP00000009291 | ENSCAFP00000038421 | Cyclin A1; Belongs to the cyclin family. | F-box protein 5. | 0.550 |
CCNA1 | PSMC5 | ENSCAFP00000009291 | ENSCAFP00000018768 | Cyclin A1; Belongs to the cyclin family. | Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. | 0.543 |
CCNA1 | RUVBL1 | ENSCAFP00000009291 | ENSCAFP00000006114 | Cyclin A1; Belongs to the cyclin family. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.513 |
CCNA1 | USP37 | ENSCAFP00000009291 | ENSCAFP00000021817 | Cyclin A1; Belongs to the cyclin family. | Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 an [...] | 0.565 |
CCNA2 | CCNA1 | ENSCAFP00000006129 | ENSCAFP00000009291 | Cyclin A2; Belongs to the cyclin family. | Cyclin A1; Belongs to the cyclin family. | 0.954 |
CCNA2 | FBXO5 | ENSCAFP00000006129 | ENSCAFP00000038421 | Cyclin A2; Belongs to the cyclin family. | F-box protein 5. | 0.695 |
CCNA2 | PSMC5 | ENSCAFP00000006129 | ENSCAFP00000018768 | Cyclin A2; Belongs to the cyclin family. | Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. | 0.546 |
CCNA2 | RUVBL1 | ENSCAFP00000006129 | ENSCAFP00000006114 | Cyclin A2; Belongs to the cyclin family. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.522 |
CCNA2 | USP37 | ENSCAFP00000006129 | ENSCAFP00000021817 | Cyclin A2; Belongs to the cyclin family. | Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 an [...] | 0.578 |
CCNA2 | USP7 | ENSCAFP00000006129 | ENSCAFP00000028037 | Cyclin A2; Belongs to the cyclin family. | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. | 0.458 |
FBXO5 | CCNA1 | ENSCAFP00000038421 | ENSCAFP00000009291 | F-box protein 5. | Cyclin A1; Belongs to the cyclin family. | 0.550 |
FBXO5 | CCNA2 | ENSCAFP00000038421 | ENSCAFP00000006129 | F-box protein 5. | Cyclin A2; Belongs to the cyclin family. | 0.695 |
FBXO5 | TRAIP | ENSCAFP00000038421 | ENSCAFP00000016303 | F-box protein 5. | TRAF interacting protein. | 0.722 |
FBXO5 | USP37 | ENSCAFP00000038421 | ENSCAFP00000021817 | F-box protein 5. | Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 an [...] | 0.536 |
JOSD1 | USP37 | ENSCAFP00000001970 | ENSCAFP00000021817 | Josephin domain containing 1. | Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 an [...] | 0.602 |
JOSD1 | USP7 | ENSCAFP00000001970 | ENSCAFP00000028037 | Josephin domain containing 1. | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. | 0.631 |
JOSD1 | USP9X | ENSCAFP00000001970 | ENSCAFP00000059613 | Josephin domain containing 1. | UCH domain-containing protein. | 0.601 |
MED13 | USP37 | ENSCAFP00000026124 | ENSCAFP00000021817 | Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 an [...] | 0.542 |
PSMC5 | CCNA1 | ENSCAFP00000018768 | ENSCAFP00000009291 | Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. | Cyclin A1; Belongs to the cyclin family. | 0.543 |