IRAK1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

IRAK1

Interleukin 1 receptor associated kinase 1. (750 aa)

Predicted Functional Partners:

MYD88

0.999

TRAF6

0.999

IRAK4

0.996

TAB2

0.992

IKBKG

0.985

TOLLIP

0.960

PELI1

0.936

PELI3

0.916

PELI2

0.909

IRAK2

0.905

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IKBKG	IRAK1	ENSCAFP00000028998	ENSCAFP00000047467	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Interleukin 1 receptor associated kinase 1.	0.985
IKBKG	IRAK2	ENSCAFP00000028998	ENSCAFP00000007680	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Interleukin 1 receptor associated kinase 2.	0.892
IKBKG	IRAK4	ENSCAFP00000028998	ENSCAFP00000014260	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Interleukin 1 receptor associated kinase 4.	0.997
IKBKG	MYD88	ENSCAFP00000028998	ENSCAFP00000007386	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	MYD88 innate immune signal transduction adaptor.	0.968
IKBKG	PELI1	ENSCAFP00000028998	ENSCAFP00000004720	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.553
IKBKG	PELI2	ENSCAFP00000028998	ENSCAFP00000022404	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Pellino E3 ubiquitin protein ligase family member 2.	0.537
IKBKG	PELI3	ENSCAFP00000028998	ENSCAFP00000042927	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.590
IKBKG	TAB2	ENSCAFP00000028998	ENSCAFP00000000532	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.996
IKBKG	TRAF6	ENSCAFP00000028998	ENSCAFP00000010159	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.998
IRAK1	IKBKG	ENSCAFP00000047467	ENSCAFP00000028998	Interleukin 1 receptor associated kinase 1.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.985
IRAK1	IRAK2	ENSCAFP00000047467	ENSCAFP00000007680	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor associated kinase 2.	0.905
IRAK1	IRAK4	ENSCAFP00000047467	ENSCAFP00000014260	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor associated kinase 4.	0.996
IRAK1	MYD88	ENSCAFP00000047467	ENSCAFP00000007386	Interleukin 1 receptor associated kinase 1.	MYD88 innate immune signal transduction adaptor.	0.999
IRAK1	PELI1	ENSCAFP00000047467	ENSCAFP00000004720	Interleukin 1 receptor associated kinase 1.	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.936
IRAK1	PELI2	ENSCAFP00000047467	ENSCAFP00000022404	Interleukin 1 receptor associated kinase 1.	Pellino E3 ubiquitin protein ligase family member 2.	0.909
IRAK1	PELI3	ENSCAFP00000047467	ENSCAFP00000042927	Interleukin 1 receptor associated kinase 1.	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.916
IRAK1	TAB2	ENSCAFP00000047467	ENSCAFP00000000532	Interleukin 1 receptor associated kinase 1.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.992
IRAK1	TOLLIP	ENSCAFP00000047467	ENSCAFP00000062384	Interleukin 1 receptor associated kinase 1.	Toll interacting protein.	0.960
IRAK1	TRAF6	ENSCAFP00000047467	ENSCAFP00000010159	Interleukin 1 receptor associated kinase 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.999
IRAK2	IKBKG	ENSCAFP00000007680	ENSCAFP00000028998	Interleukin 1 receptor associated kinase 2.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.892