node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APP | CTRB2 | ENSCAFP00000012583 | ENSCAFP00000029763 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Chymotrypsin 2 chain A; Belongs to the peptidase S1 family. | 0.874 |
APP | CTRL | ENSCAFP00000012583 | ENSCAFP00000030158 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Chymotrypsin like; Belongs to the peptidase S1 family. | 0.454 |
APP | LOC475521 | ENSCAFP00000012583 | ENSCAFP00000005682 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Cationic trypsin. | 0.975 |
APP | LOC479649 | ENSCAFP00000012583 | ENSCAFP00000032443 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.874 |
APP | PLG | ENSCAFP00000012583 | ENSCAFP00000001078 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Plasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...] | 0.495 |
CEL | CLPS | ENSCAFP00000054562 | ENSCAFP00000001934 | Carboxyl ester lipase; Belongs to the type-B carboxylesterase/lipase family. | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | 0.920 |
CEL | CTRB2 | ENSCAFP00000054562 | ENSCAFP00000029763 | Carboxyl ester lipase; Belongs to the type-B carboxylesterase/lipase family. | Chymotrypsin 2 chain A; Belongs to the peptidase S1 family. | 0.884 |
CEL | CTRL | ENSCAFP00000054562 | ENSCAFP00000030158 | Carboxyl ester lipase; Belongs to the type-B carboxylesterase/lipase family. | Chymotrypsin like; Belongs to the peptidase S1 family. | 0.906 |
CEL | LOC475521 | ENSCAFP00000054562 | ENSCAFP00000005682 | Carboxyl ester lipase; Belongs to the type-B carboxylesterase/lipase family. | Cationic trypsin. | 0.415 |
CEL | LOC478196 | ENSCAFP00000054562 | ENSCAFP00000046922 | Carboxyl ester lipase; Belongs to the type-B carboxylesterase/lipase family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.950 |
CEL | LOC479649 | ENSCAFP00000054562 | ENSCAFP00000032443 | Carboxyl ester lipase; Belongs to the type-B carboxylesterase/lipase family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.887 |
CLPS | CEL | ENSCAFP00000001934 | ENSCAFP00000054562 | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | Carboxyl ester lipase; Belongs to the type-B carboxylesterase/lipase family. | 0.920 |
CLPS | CTRB2 | ENSCAFP00000001934 | ENSCAFP00000029763 | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | Chymotrypsin 2 chain A; Belongs to the peptidase S1 family. | 0.777 |
CLPS | CTRL | ENSCAFP00000001934 | ENSCAFP00000030158 | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | Chymotrypsin like; Belongs to the peptidase S1 family. | 0.718 |
CLPS | LOC475521 | ENSCAFP00000001934 | ENSCAFP00000005682 | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | Cationic trypsin. | 0.432 |
CLPS | LOC478196 | ENSCAFP00000001934 | ENSCAFP00000046922 | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.739 |
CLPS | LOC479649 | ENSCAFP00000001934 | ENSCAFP00000032443 | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.740 |
CTRB2 | APP | ENSCAFP00000029763 | ENSCAFP00000012583 | Chymotrypsin 2 chain A; Belongs to the peptidase S1 family. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.874 |
CTRB2 | CEL | ENSCAFP00000029763 | ENSCAFP00000054562 | Chymotrypsin 2 chain A; Belongs to the peptidase S1 family. | Carboxyl ester lipase; Belongs to the type-B carboxylesterase/lipase family. | 0.884 |
CTRB2 | CLPS | ENSCAFP00000029763 | ENSCAFP00000001934 | Chymotrypsin 2 chain A; Belongs to the peptidase S1 family. | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | 0.777 |