STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CBD103Uncharacterized protein. (122 aa)    
Predicted Functional Partners:
DEFB1
Beta-defensin 1.
     
 0.979
DEFB4A
Beta-defensin 102.
     
 0.972
ASIP
Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).
      
 0.916
LOC100855846
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
      
 0.788
CBD107
Beta-defensin 107A.
      
 0.788
DEFB122
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
      
 0.787
CBD108
Uncharacterized protein.
      
 0.787
CCR2
C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.
     
 0.786
CCR6
C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.
     
 0.716
DEFB124
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
     
 0.713
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.