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TFPI protein (Canis lupus) - STRING interaction network
"TFPI" - Tissue factor pathway inhibitor in Canis lupus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TFPITissue factor pathway inhibitor (396 aa)    
Predicted Functional Partners:
F7
Coagulation factor VII precursor (446 aa)
     
  0.981
F3
Tissue factor precursor ; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF-VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade (292 aa)
     
 
  0.975
F10
Coagulation factor X (497 aa)
     
  0.956
ACE
Angiotensin converting enzyme (1314 aa)
     
   
  0.951
ACE2
Angiotensin-converting enzyme 2 precursor (809 aa)
     
   
  0.949
FBN1
Fibrillin 1 (2871 aa)
     
   
  0.792
FBN2
Fibrillin 2 (2921 aa)
     
   
  0.785
THBD
Thrombomodulin precursor ; Thrombomodulin is a specific endothelial cell receptor that forms a 1-1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated (By similarity) (578 aa)
     
   
  0.777
PLG
Plasminogen Plasmin heavy chain A Plasmin light chain B; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remo [...] (812 aa)
     
  0.777
F2
Coagulation factor II (thrombin); Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (621 aa)
     
  0.775
Your Current Organism:
Canis lupus
NCBI taxonomy Id: 9615
Other names: C. lupus, C. lupus familiaris, Canidae, Canis, Canis canis, Canis domesticus, Canis familiaris, Canis lupus, Canis lupus familiaris, beagle dog, beagle dogs, dog, dog, coyote, wolf, fox, dogs, gray wolf, grey wolf
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