STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APH1BGamma-secretase subunit APH-1B. (257 aa)    
Predicted Functional Partners:
PSENEN
Gamma-secretase subunit PEN-2.
   
 0.996
NCSTN
Nicastrin.
   
 0.996
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
 0.994
PSEN2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
 0.974
NOTCH3
LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 3.
    
 0.922
NOTCH2
Neurogenic locus notch homolog protein 2.
    
 0.913
APH1A
Gamma-secretase subunit APH-1A isoform X1.
  
  
 
0.902
GPSM3
Neurogenic locus notch homolog protein 4 isoform X1.
     
 0.902
BACE2
Beta-secretase 2; Belongs to the peptidase A1 family.
      
 0.735
APP
Amyloid-beta A4 protein isoform X1.
    
 0.691
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.