STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MICU1Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. [...] (480 aa)    
Predicted Functional Partners:
MCU
Mitochondrial calcium uniporter.
    
 0.997
SMDT1
Single-pass membrane protein with aspartate rich tail 1.
    
 0.994
MICU2
Mitochondrial calcium uptake 2.
    
0.993
G1LCX6_AILME
MCU domain-containing protein.
    
 0.965
G1M236_AILME
MCU domain-containing protein.
    
 0.947
G1LVE3_AILME
Uncharacterized protein.
   
0.794
MICU3
Uncharacterized protein.
   
0.794
PHB2
Prohibitin.
    
 0.791
MCUR1
Mitochondrial calcium uniporter regulator 1.
      
 0.787
SLC25A23
Solute carrier family 25 member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.748
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.