STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RNF182E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. (247 aa)    
Predicted Functional Partners:
TBC1D30
TBC1 domain family member 30.
      
 0.750
LHFPL2
LHFPL tetraspan subfamily member 2.
      
 0.748
NRIP3
Nuclear receptor interacting protein 3.
   
  
 0.718
OCIAD2
OCIA domain containing 2.
      
 0.700
ARHGAP12
Rho GTPase activating protein 12.
     
 0.646
SLC39A6
Solute carrier family 39 member 6.
      
 0.614
RAB3C
RAB3C, member RAS oncogene family.
      
 0.609
SYTL2
Synaptotagmin like 2.
    
 0.590
RNF186
Ring finger protein 186.
      
 0.534
PKIB
cAMP-dependent protein kinase inhibitor; Belongs to the PKI family.
      
 0.531
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
Server load: low (32%) [HD]