node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dole_0748 | Dole_0750 | Dole_0748 | Dole_0750 | Proto-chlorophyllide reductase 57 kD subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; nitrite and sulphite reductase 4Fe-4S region; Proto-chlorophyllide reductase 57 kD subunit; KEGG: dde:Dde_2390 dissimilatory sulfite reductase (desulfoviridin) alpha and beta subunits-like. | PFAM: MOSC domain containing protein; KEGG: drm:Dred_2266 MOSC domain containing protein. | 0.424 |
Dole_0748 | thiM | Dole_0748 | Dole_0749 | Proto-chlorophyllide reductase 57 kD subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; nitrite and sulphite reductase 4Fe-4S region; Proto-chlorophyllide reductase 57 kD subunit; KEGG: dde:Dde_2390 dissimilatory sulfite reductase (desulfoviridin) alpha and beta subunits-like. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.461 |
Dole_0750 | Dole_0748 | Dole_0750 | Dole_0748 | PFAM: MOSC domain containing protein; KEGG: drm:Dred_2266 MOSC domain containing protein. | Proto-chlorophyllide reductase 57 kD subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; nitrite and sulphite reductase 4Fe-4S region; Proto-chlorophyllide reductase 57 kD subunit; KEGG: dde:Dde_2390 dissimilatory sulfite reductase (desulfoviridin) alpha and beta subunits-like. | 0.424 |
Dole_0750 | metXA | Dole_0750 | Dole_0752 | PFAM: MOSC domain containing protein; KEGG: drm:Dred_2266 MOSC domain containing protein. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.473 |
Dole_0750 | thiM | Dole_0750 | Dole_0749 | PFAM: MOSC domain containing protein; KEGG: drm:Dred_2266 MOSC domain containing protein. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.701 |
Dole_2079 | Dole_2517 | Dole_2079 | Dole_2517 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Phosphomethylpyrimidine kinase; KEGG: tte:TTE2235 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. | 0.579 |
Dole_2079 | thiC | Dole_2079 | Dole_2427 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | 0.463 |
Dole_2079 | thiE | Dole_2079 | Dole_1765 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Thiamine-phosphate pyrophosphorylase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.824 |
Dole_2079 | thiM | Dole_2079 | Dole_0749 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.474 |
Dole_2502 | Dole_2517 | Dole_2502 | Dole_2517 | PFAM: thiamineS protein; KEGG: drm:Dred_2272 hypothetical protein. | Phosphomethylpyrimidine kinase; KEGG: tte:TTE2235 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. | 0.805 |
Dole_2502 | mqnC | Dole_2502 | Dole_1272 | PFAM: thiamineS protein; KEGG: drm:Dred_2272 hypothetical protein. | Radical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). | 0.725 |
Dole_2502 | mqnE | Dole_2502 | Dole_1271 | PFAM: thiamineS protein; KEGG: drm:Dred_2272 hypothetical protein. | Radical SAM domain protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. | 0.725 |
Dole_2502 | thiC | Dole_2502 | Dole_2427 | PFAM: thiamineS protein; KEGG: drm:Dred_2272 hypothetical protein. | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | 0.839 |
Dole_2502 | thiE | Dole_2502 | Dole_1765 | PFAM: thiamineS protein; KEGG: drm:Dred_2272 hypothetical protein. | Thiamine-phosphate pyrophosphorylase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.902 |
Dole_2502 | thiM | Dole_2502 | Dole_0749 | PFAM: thiamineS protein; KEGG: drm:Dred_2272 hypothetical protein. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.515 |
Dole_2517 | Dole_2079 | Dole_2517 | Dole_2079 | Phosphomethylpyrimidine kinase; KEGG: tte:TTE2235 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.579 |
Dole_2517 | Dole_2502 | Dole_2517 | Dole_2502 | Phosphomethylpyrimidine kinase; KEGG: tte:TTE2235 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. | PFAM: thiamineS protein; KEGG: drm:Dred_2272 hypothetical protein. | 0.805 |
Dole_2517 | mqnC | Dole_2517 | Dole_1272 | Phosphomethylpyrimidine kinase; KEGG: tte:TTE2235 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. | Radical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). | 0.412 |
Dole_2517 | mqnE | Dole_2517 | Dole_1271 | Phosphomethylpyrimidine kinase; KEGG: tte:TTE2235 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. | Radical SAM domain protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. | 0.412 |
Dole_2517 | thiC | Dole_2517 | Dole_2427 | Phosphomethylpyrimidine kinase; KEGG: tte:TTE2235 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | 0.990 |