node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dole_0374 | uppP | Dole_0374 | Dole_1174 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Bacitracin resistance protein BacA; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.417 |
Dole_0478 | mraY | Dole_0478 | Dole_2790 | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.542 |
Dole_0478 | uppP | Dole_0478 | Dole_1174 | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | Bacitracin resistance protein BacA; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.924 |
Dole_1172 | Dole_1173 | Dole_1172 | Dole_1173 | KEGG: sat:SYN_01357 hypothetical cytosolic protein. | PFAM: Lytic transglycosylase catalytic; KEGG: sat:SYN_02783 soluble lytic murein transglycosylase. | 0.617 |
Dole_1172 | uppP | Dole_1172 | Dole_1174 | KEGG: sat:SYN_01357 hypothetical cytosolic protein. | Bacitracin resistance protein BacA; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.424 |
Dole_1173 | Dole_1172 | Dole_1173 | Dole_1172 | PFAM: Lytic transglycosylase catalytic; KEGG: sat:SYN_02783 soluble lytic murein transglycosylase. | KEGG: sat:SYN_01357 hypothetical cytosolic protein. | 0.617 |
Dole_1173 | uppP | Dole_1173 | Dole_1174 | PFAM: Lytic transglycosylase catalytic; KEGG: sat:SYN_02783 soluble lytic murein transglycosylase. | Bacitracin resistance protein BacA; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.541 |
Dole_1175 | Dole_1177 | Dole_1175 | Dole_1177 | Phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: sfu:Sfum_0481 phosphomannomutase. | Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.543 |
Dole_1175 | uppP | Dole_1175 | Dole_1174 | Phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: sfu:Sfum_0481 phosphomannomutase. | Bacitracin resistance protein BacA; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.661 |
Dole_1177 | Dole_1175 | Dole_1177 | Dole_1175 | Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: sfu:Sfum_0481 phosphomannomutase. | 0.543 |
Dole_1177 | uppP | Dole_1177 | Dole_1174 | Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Bacitracin resistance protein BacA; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.404 |
macB | uppP | Dole_1627 | Dole_1174 | ABC transporter-related protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | Bacitracin resistance protein BacA; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.415 |
mraY | Dole_0478 | Dole_2790 | Dole_0478 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.542 |
mraY | uppP | Dole_2790 | Dole_1174 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Bacitracin resistance protein BacA; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.914 |
queA | uppP | Dole_0083 | Dole_1174 | Queuosine biosynthesis protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Bacitracin resistance protein BacA; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.449 |
uppP | Dole_0374 | Dole_1174 | Dole_0374 | Bacitracin resistance protein BacA; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.417 |
uppP | Dole_0478 | Dole_1174 | Dole_0478 | Bacitracin resistance protein BacA; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.924 |
uppP | Dole_1172 | Dole_1174 | Dole_1172 | Bacitracin resistance protein BacA; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | KEGG: sat:SYN_01357 hypothetical cytosolic protein. | 0.424 |
uppP | Dole_1173 | Dole_1174 | Dole_1173 | Bacitracin resistance protein BacA; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | PFAM: Lytic transglycosylase catalytic; KEGG: sat:SYN_02783 soluble lytic murein transglycosylase. | 0.541 |
uppP | Dole_1175 | Dole_1174 | Dole_1175 | Bacitracin resistance protein BacA; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | Phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: sfu:Sfum_0481 phosphomannomutase. | 0.661 |