node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dole_0467 | fhs | Dole_0467 | Dole_3059 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; KEGG: sfu:Sfum_1671 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sfu:Sfum_2687 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.755 |
Dole_0467 | folD | Dole_0467 | Dole_2033 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; KEGG: sfu:Sfum_1671 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.539 |
Dole_0467 | glyA | Dole_0467 | Dole_2082 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; KEGG: sfu:Sfum_1671 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.695 |
Dole_0467 | guaA | Dole_0467 | Dole_0966 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; KEGG: sfu:Sfum_1671 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.595 |
Dole_1515 | Dole_1516 | Dole_1515 | Dole_1516 | PFAM: MGS domain protein; KEGG: neu:NE0876 probable phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclodydrolase transmembrane protein. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: sfu:Sfum_3083 AICARFT/IMPCHase bienzyme, formylation region. | 0.993 |
Dole_1515 | fhs | Dole_1515 | Dole_3059 | PFAM: MGS domain protein; KEGG: neu:NE0876 probable phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclodydrolase transmembrane protein. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sfu:Sfum_2687 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.771 |
Dole_1515 | folD | Dole_1515 | Dole_2033 | PFAM: MGS domain protein; KEGG: neu:NE0876 probable phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclodydrolase transmembrane protein. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.590 |
Dole_1515 | glyA | Dole_1515 | Dole_2082 | PFAM: MGS domain protein; KEGG: neu:NE0876 probable phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclodydrolase transmembrane protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.794 |
Dole_1515 | guaA | Dole_1515 | Dole_0966 | PFAM: MGS domain protein; KEGG: neu:NE0876 probable phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclodydrolase transmembrane protein. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.802 |
Dole_1515 | purC | Dole_1515 | Dole_2369 | PFAM: MGS domain protein; KEGG: neu:NE0876 probable phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclodydrolase transmembrane protein. | KEGG: ppd:Ppro_3066 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. | 0.861 |
Dole_1515 | purE | Dole_1515 | Dole_1427 | PFAM: MGS domain protein; KEGG: neu:NE0876 probable phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclodydrolase transmembrane protein. | Phosphoribosylamine--glycine ligase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR); Belongs to the GARS family. | 0.992 |
Dole_1515 | purL | Dole_1515 | Dole_0482 | PFAM: MGS domain protein; KEGG: neu:NE0876 probable phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclodydrolase transmembrane protein. | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] | 0.982 |
Dole_1515 | purN | Dole_1515 | Dole_1645 | PFAM: MGS domain protein; KEGG: neu:NE0876 probable phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclodydrolase transmembrane protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.972 |
Dole_1516 | Dole_1515 | Dole_1516 | Dole_1515 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: sfu:Sfum_3083 AICARFT/IMPCHase bienzyme, formylation region. | PFAM: MGS domain protein; KEGG: neu:NE0876 probable phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclodydrolase transmembrane protein. | 0.993 |
Dole_1516 | fhs | Dole_1516 | Dole_3059 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: sfu:Sfum_3083 AICARFT/IMPCHase bienzyme, formylation region. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sfu:Sfum_2687 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.979 |
Dole_1516 | folD | Dole_1516 | Dole_2033 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: sfu:Sfum_3083 AICARFT/IMPCHase bienzyme, formylation region. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.963 |
Dole_1516 | glyA | Dole_1516 | Dole_2082 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: sfu:Sfum_3083 AICARFT/IMPCHase bienzyme, formylation region. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.978 |
Dole_1516 | guaA | Dole_1516 | Dole_0966 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: sfu:Sfum_3083 AICARFT/IMPCHase bienzyme, formylation region. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.797 |
Dole_1516 | purC | Dole_1516 | Dole_2369 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: sfu:Sfum_3083 AICARFT/IMPCHase bienzyme, formylation region. | KEGG: ppd:Ppro_3066 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. | 0.861 |
Dole_1516 | purE | Dole_1516 | Dole_1427 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: sfu:Sfum_3083 AICARFT/IMPCHase bienzyme, formylation region. | Phosphoribosylamine--glycine ligase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR); Belongs to the GARS family. | 0.991 |