STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SERPINE1Serpin peptidase inhibitor, clade E, member 1; Belongs to the serpin family. (400 aa)    
Predicted Functional Partners:
VTN
SMB domain-containing protein
   
 0.996
PLAT
Plasminogen activator, tissue type
   
 0.993
PLAU
Plasminogen activator, urokinase
   
 0.979
PLAUR
Plasminogen activator, urokinase receptor
   
 
 0.972
PLG
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4.
    
 0.875
VLDLR
Very low density lipoprotein receptor
     
 0.867
SERPINE2
Serpin family E member 2; Belongs to the serpin family.
   
 
0.850
SMAD2
Mothers against decapentaplegic homolog
     
 0.835
SMAD7
Mothers against decapentaplegic homolog
   
 
 0.816
FN1
Fibronectin 1
   
 
 0.798
Your Current Organism:
Mustela putorius furo
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo Linnaeus, 1758, black ferret, domestic ferret, ferret
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