STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRDM2PR domain zinc finger protein 2. (1634 aa)    
Predicted Functional Partners:
CAMKMT
Calmodulin-lysine N-methyltransferase.
     
 0.834
EP300
Histone acetyltransferase p300.
   
 
 0.811
ASH1L
Histone-lysine N-methyltransferase ASH1L.
  
 0.799
EHMT2
Histone-lysine N-methyltransferase EHMT2 isoform X1.
    
 0.796
BRCA2
Breast cancer type 2 susceptibility protein homolog.
      
 0.748
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.722
SETDB1
Histone-lysine N-methyltransferase SETDB1 isoform X1.
    
 0.702
WHSC1L1
Histone-lysine N-methyltransferase NSD3 isoform X1.
   
 0.700
KMT2D
Histone-lysine N-methyltransferase 2D.
   
 
 0.692
LOC102739775
Breast cancer type 1 susceptibility protein homolog.
      
 0.647
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.