TELO2 protein (Leptonychotes weddellii) - STRING interaction network

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[Homology]

Score

TELO2

Telomere length regulation protein TEL2 homolog. (822 aa)

Predicted Functional Partners:

FANCM

0.999

TTI1

0.998

MTOR

0.996

RUVBL2

0.934

LOC102748176

0.932

TTI2

0.922

ATM

0.876

SH3BP5L

0.807

LOC102744718

0.803

PWWP2A

0.775

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	FANCM	A0A2U3YJR1	A0A2U3X6T4	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Fanconi anemia group M protein.	0.611
ATM	LOC102744718	A0A2U3YJR1	A0A2U3Z762	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Transformation/transcription domain-associated protein-like.	0.416
ATM	MTOR	A0A2U3YJR1	A0A2U3XVT2	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.630
ATM	TELO2	A0A2U3YJR1	A0A2U3YE69	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Telomere length regulation protein TEL2 homolog.	0.876
ATM	TTI2	A0A2U3YJR1	A0A2U3YWS2	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	TELO2-interacting protein 2.	0.437
FANCM	ATM	A0A2U3X6T4	A0A2U3YJR1	Fanconi anemia group M protein.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.611
FANCM	LOC102748176	A0A2U3X6T4	A0A2U3Y5D8	Fanconi anemia group M protein.	Fanconi anemia-associated protein of 24 kDa.	0.999
FANCM	PWWP2A	A0A2U3X6T4	A0A2U3YQD8	Fanconi anemia group M protein.	PWWP domain-containing protein 2A.	0.609
FANCM	TELO2	A0A2U3X6T4	A0A2U3YE69	Fanconi anemia group M protein.	Telomere length regulation protein TEL2 homolog.	0.999
LOC102744718	ATM	A0A2U3Z762	A0A2U3YJR1	Transformation/transcription domain-associated protein-like.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.416
LOC102744718	MTOR	A0A2U3Z762	A0A2U3XVT2	Transformation/transcription domain-associated protein-like.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.703
LOC102744718	RUVBL2	A0A2U3Z762	A0A2U3Z341	Transformation/transcription domain-associated protein-like.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.940
LOC102744718	TELO2	A0A2U3Z762	A0A2U3YE69	Transformation/transcription domain-associated protein-like.	Telomere length regulation protein TEL2 homolog.	0.803
LOC102744718	TTI1	A0A2U3Z762	A0A2U3Z195	Transformation/transcription domain-associated protein-like.	TELO2-interacting protein 1 homolog.	0.508
LOC102744718	TTI2	A0A2U3Z762	A0A2U3YWS2	Transformation/transcription domain-associated protein-like.	TELO2-interacting protein 2.	0.496
LOC102748176	FANCM	A0A2U3Y5D8	A0A2U3X6T4	Fanconi anemia-associated protein of 24 kDa.	Fanconi anemia group M protein.	0.999
LOC102748176	TELO2	A0A2U3Y5D8	A0A2U3YE69	Fanconi anemia-associated protein of 24 kDa.	Telomere length regulation protein TEL2 homolog.	0.932
MTOR	ATM	A0A2U3XVT2	A0A2U3YJR1	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.630
MTOR	LOC102744718	A0A2U3XVT2	A0A2U3Z762	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Transformation/transcription domain-associated protein-like.	0.703
MTOR	PWWP2A	A0A2U3XVT2	A0A2U3YQD8	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	PWWP domain-containing protein 2A.	0.630