STRINGSTRING
folD protein (Cupriavidus taiwanensis) - STRING interaction network
"folD" - Bifunctional protein FolD in Cupriavidus taiwanensis
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folDBifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (283 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (415 aa)
 
 
  0.994
purH
Bifunctional purine biosynthesis protein PurH; Evidence 2a - Function of homologous gene experimentally demonstrated in an other organism; Product type e - enzyme (524 aa)
 
  0.983
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (375 aa)
   
 
  0.977
purU
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) (288 aa)
 
 
  0.970
metF
Methylenetetrahydrofolate reductase; Evidence 2a - Function of homologous gene experimentally demonstrated in an other organism; Product type e - enzyme (276 aa)
   
 
  0.966
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (222 aa)
 
 
  0.964
CAP62866.1
5-formyltetrahydrofolate cyclo-ligase; Evidence 3 - Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe - putative enzyme; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family (195 aa)
   
 
  0.963
fmt
Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus (337 aa)
 
  0.950
CAQ72047.1
Putative formyltransferase; Evidence 3 - Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e - enzyme (312 aa)
 
 
  0.940
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP (539 aa)
   
   
  0.939
Your Current Organism:
Cupriavidus taiwanensis
NCBI taxonomy Id: 977880
Other names: C. taiwanensis LMG 19424, Cupriavidus taiwanensis, Cupriavidus taiwanensis LMG 19424, Cupriavidus taiwanensis str. LMG 19424, Cupriavidus taiwanensis strain LMG 19424
Server load: low (14%) [HD]