STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHC1SHC adaptor protein 1. (583 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor bound protein 2.
   
 0.993
EGFR
Receptor protein-tyrosine kinase.
    
 0.984
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
   
 0.982
ERBB2
Receptor protein-tyrosine kinase.
    
 0.981
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2.
   
 0.980
IGF1R
Tyrosine-protein kinase receptor.
    
 0.971
GAB1
GRB2 associated binding protein 1.
    
 0.970
INSR
Tyrosine-protein kinase receptor.
    
 0.969
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
   
 0.965
NTRK3
Tyrosine-protein kinase receptor.
   
 0.965
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.