STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMBIM4Uncharacterized protein; Belongs to the BI1 family. (238 aa)    
Predicted Functional Partners:
LEMD3
LEM domain containing 3.
      
 0.528
PML
Promyelocytic leukemia.
    
 
 0.527
SIGMAR1
Sigma non-opioid intracellular receptor 1.
      
 0.519
TMEM147
Transmembrane protein 147.
   
  
 0.474
DDX58
DExD/H-box helicase 58.
      
 0.454
RCN2
Reticulocalbin 2.
      
 0.451
GHITM
Growth hormone inducible transmembrane protein; Belongs to the BI1 family.
   
  
 0.449
TMEM97
Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
     
 0.444
PDZK1IP1
PDZK1 interacting protein 1.
      
 0.441
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.