node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBS | FLAD1 | ENSLAFP00000008333 | ENSLAFP00000014966 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | 0.881 |
CBS | MTHFR | ENSLAFP00000008333 | ENSLAFP00000009208 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.816 |
CBS | MTR | ENSLAFP00000008333 | ENSLAFP00000005484 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.970 |
CBS | MTRR | ENSLAFP00000008333 | ENSLAFP00000015552 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.883 |
CIAPIN1 | MTRR | ENSLAFP00000001778 | ENSLAFP00000015552 | Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.735 |
CYP4B1 | MTRR | ENSLAFP00000009325 | ENSLAFP00000015552 | Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.893 |
CYP4V2 | MTRR | ENSLAFP00000014746 | ENSLAFP00000015552 | Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.910 |
FLAD1 | CBS | ENSLAFP00000014966 | ENSLAFP00000008333 | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.881 |
FLAD1 | MTHFR | ENSLAFP00000014966 | ENSLAFP00000009208 | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.725 |
FLAD1 | MTRR | ENSLAFP00000014966 | ENSLAFP00000015552 | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.804 |
IGFBP7 | MTRR | ENSLAFP00000016404 | ENSLAFP00000015552 | Insulin like growth factor binding protein 7. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.723 |
MMACHC | MMADHC | ENSLAFP00000014580 | ENSLAFP00000014233 | Metabolism of cobalamin associated C. | Metabolism of cobalamin associated D. | 0.880 |
MMACHC | MTR | ENSLAFP00000014580 | ENSLAFP00000005484 | Metabolism of cobalamin associated C. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.840 |
MMACHC | MTRR | ENSLAFP00000014580 | ENSLAFP00000015552 | Metabolism of cobalamin associated C. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.861 |
MMADHC | MMACHC | ENSLAFP00000014233 | ENSLAFP00000014580 | Metabolism of cobalamin associated D. | Metabolism of cobalamin associated C. | 0.880 |
MMADHC | MTR | ENSLAFP00000014233 | ENSLAFP00000005484 | Metabolism of cobalamin associated D. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.881 |
MMADHC | MTRR | ENSLAFP00000014233 | ENSLAFP00000015552 | Metabolism of cobalamin associated D. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.881 |
MTHFR | CBS | ENSLAFP00000009208 | ENSLAFP00000008333 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.816 |
MTHFR | FLAD1 | ENSLAFP00000009208 | ENSLAFP00000014966 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | 0.725 |
MTHFR | MTR | ENSLAFP00000009208 | ENSLAFP00000005484 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.997 |