node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD4 | IFNG | ENSLAFP00000028787 | ENSLAFP00000003740 | CD4 molecule. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.891 |
CD4 | IL10 | ENSLAFP00000028787 | ENSLAFP00000016293 | CD4 molecule. | Interleukin 10. | 0.851 |
CD4 | IL17A | ENSLAFP00000028787 | ENSLAFP00000001288 | CD4 molecule. | Interleukin 17A. | 0.807 |
CD4 | IL18 | ENSLAFP00000028787 | ENSLAFP00000022754 | CD4 molecule. | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. | 0.583 |
CD4 | IL1B | ENSLAFP00000028787 | ENSLAFP00000003388 | CD4 molecule. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.739 |
CD4 | IL4 | ENSLAFP00000028787 | ENSLAFP00000008191 | CD4 molecule. | Uncharacterized protein. | 0.788 |
CD4 | IL6 | ENSLAFP00000028787 | ENSLAFP00000013050 | CD4 molecule. | Interleukin 6. | 0.839 |
IFNAR1 | IFNG | ENSLAFP00000011759 | ENSLAFP00000003740 | Interferon alpha and beta receptor subunit 1. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.952 |
IFNAR1 | IL10 | ENSLAFP00000011759 | ENSLAFP00000016293 | Interferon alpha and beta receptor subunit 1. | Interleukin 10. | 0.888 |
IFNAR1 | IL10RA | ENSLAFP00000011759 | ENSLAFP00000007348 | Interferon alpha and beta receptor subunit 1. | Interleukin 10 receptor subunit alpha. | 0.754 |
IFNAR1 | IL4 | ENSLAFP00000011759 | ENSLAFP00000008191 | Interferon alpha and beta receptor subunit 1. | Uncharacterized protein. | 0.717 |
IFNAR1 | IL6 | ENSLAFP00000011759 | ENSLAFP00000013050 | Interferon alpha and beta receptor subunit 1. | Interleukin 6. | 0.766 |
IFNG | CD4 | ENSLAFP00000003740 | ENSLAFP00000028787 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | CD4 molecule. | 0.891 |
IFNG | IFNAR1 | ENSLAFP00000003740 | ENSLAFP00000011759 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Interferon alpha and beta receptor subunit 1. | 0.952 |
IFNG | IL10 | ENSLAFP00000003740 | ENSLAFP00000016293 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Interleukin 10. | 0.942 |
IFNG | IL10RA | ENSLAFP00000003740 | ENSLAFP00000007348 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Interleukin 10 receptor subunit alpha. | 0.769 |
IFNG | IL10RB | ENSLAFP00000003740 | ENSLAFP00000011753 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Interleukin 10 receptor subunit beta. | 0.739 |
IFNG | IL17A | ENSLAFP00000003740 | ENSLAFP00000001288 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Interleukin 17A. | 0.784 |
IFNG | IL18 | ENSLAFP00000003740 | ENSLAFP00000022754 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. | 0.730 |
IFNG | IL1B | ENSLAFP00000003740 | ENSLAFP00000003388 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.835 |