STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCNT1Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAP II) (By similarity). In case of equine infectious anemia virus (EIAV) infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Ta [...] (751 aa)    
Predicted Functional Partners:
CDK9
Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.
   
 0.999
AFF4
AF4/FMR2 family member 4.
   
 0.998
AFF1
AF4/FMR2 family member 1.
   
 0.976
HEXIM1
HEXIM P-TEFb complex subunit 1.
   
 
 0.963
LARP7
La ribonucleoprotein domain family member 7.
   
 0.962
BRD4
Bromodomain containing 4.
   
 
 0.962
CCNT2
Cyclin T2; Belongs to the cyclin family.
   
0.955
ELL2
Elongation factor for RNA polymerase II 2.
    
 0.953
CDK7
Cyclin dependent kinase 7.
   
 
 0.952
HEXIM2
HEXIM P-TEFb complex subunit 2.
   
 
 0.949
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.