node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSECAP00000044533 | NEDD8 | ENSECAP00000044533 | ENSECAP00000040498 | Ubiquitin-like domain-containing protein. | NEDD8 ubiquitin like modifier. | 0.827 |
ENSECAP00000044533 | PRKN | ENSECAP00000044533 | ENSECAP00000054587 | Ubiquitin-like domain-containing protein. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.819 |
ENSECAP00000044533 | UBA3 | ENSECAP00000044533 | ENSECAP00000043479 | Ubiquitin-like domain-containing protein. | Ubiquitin like modifier activating enzyme 3. | 0.607 |
ENSECAP00000044533 | UBA52 | ENSECAP00000044533 | ENSECAP00000018080 | Ubiquitin-like domain-containing protein. | Ubiquitin A-52 residue ribosomal protein fusion product 1. | 0.983 |
ENSECAP00000044533 | UBC | ENSECAP00000044533 | ENSECAP00000002343 | Ubiquitin-like domain-containing protein. | Ubiquitin B. | 0.781 |
ENSECAP00000044533 | UBC-2 | ENSECAP00000044533 | ENSECAP00000035675 | Ubiquitin-like domain-containing protein. | Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] | 0.781 |
ENSECAP00000044533 | UCHL1 | ENSECAP00000044533 | ENSECAP00000024797 | Ubiquitin-like domain-containing protein. | Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C- terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity); Belongs to the peptidase C12 family. | 0.775 |
NEDD8 | ENSECAP00000044533 | ENSECAP00000040498 | ENSECAP00000044533 | NEDD8 ubiquitin like modifier. | Ubiquitin-like domain-containing protein. | 0.827 |
NEDD8 | PRKN | ENSECAP00000040498 | ENSECAP00000054587 | NEDD8 ubiquitin like modifier. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.641 |
NEDD8 | RPS27A | ENSECAP00000040498 | ENSECAP00000016396 | NEDD8 ubiquitin like modifier. | Ribosomal protein S27a. | 0.823 |
NEDD8 | UBA3 | ENSECAP00000040498 | ENSECAP00000043479 | NEDD8 ubiquitin like modifier. | Ubiquitin like modifier activating enzyme 3. | 0.999 |
NEDD8 | UBA52 | ENSECAP00000040498 | ENSECAP00000018080 | NEDD8 ubiquitin like modifier. | Ubiquitin A-52 residue ribosomal protein fusion product 1. | 0.930 |
NEDD8 | UBC | ENSECAP00000040498 | ENSECAP00000002343 | NEDD8 ubiquitin like modifier. | Ubiquitin B. | 0.763 |
NEDD8 | UBC-2 | ENSECAP00000040498 | ENSECAP00000035675 | NEDD8 ubiquitin like modifier. | Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] | 0.763 |
NEDD8 | UCHL1 | ENSECAP00000040498 | ENSECAP00000024797 | NEDD8 ubiquitin like modifier. | Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C- terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity); Belongs to the peptidase C12 family. | 0.747 |
PRKN | ENSECAP00000044533 | ENSECAP00000054587 | ENSECAP00000044533 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | Ubiquitin-like domain-containing protein. | 0.819 |
PRKN | NEDD8 | ENSECAP00000054587 | ENSECAP00000040498 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | NEDD8 ubiquitin like modifier. | 0.641 |
PRKN | RPS27A | ENSECAP00000054587 | ENSECAP00000016396 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | Ribosomal protein S27a. | 0.981 |
PRKN | SNCA | ENSECAP00000054587 | ENSECAP00000043218 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | Alpha-synuclein; Belongs to the synuclein family. | 0.994 |
PRKN | UBA52 | ENSECAP00000054587 | ENSECAP00000018080 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | Ubiquitin A-52 residue ribosomal protein fusion product 1. | 0.996 |