node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENPP1 | ENPP3 | ENSSSCP00000039332 | ENSSSCP00000029207 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. | 0.905 |
ENPP1 | ITPA | ENSSSCP00000039332 | ENSSSCP00000054471 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.909 |
ENPP1 | MOCS1 | ENSSSCP00000039332 | ENSSSCP00000001730 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. | Molybdenum cofactor synthesis 1. | 0.805 |
ENPP1 | NUDT2 | ENSSSCP00000039332 | ENSSSCP00000011711 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis. | 0.917 |
ENPP1 | PDE10A | ENSSSCP00000039332 | ENSSSCP00000052616 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. | Phosphodiesterase. | 0.927 |
ENPP1 | PDE6A | ENSSSCP00000039332 | ENSSSCP00000015367 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. | Phosphodiesterase. | 0.728 |
ENPP1 | PKLR | ENSSSCP00000039332 | ENSSSCP00000036804 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.902 |
ENPP1 | PKM | ENSSSCP00000039332 | ENSSSCP00000051975 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. | Multifunctional fusion protein; Belongs to the pyruvate kinase family. | 0.902 |
ENPP1 | PLBD1 | ENSSSCP00000039332 | ENSSSCP00000051408 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. | Heat-stable enterotoxin receptor; Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.927 |
ENPP3 | ENPP1 | ENSSSCP00000029207 | ENSSSCP00000039332 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. | Ectonucleotide pyrophosphatase/phosphodiesterase 1. | 0.905 |
ENPP3 | ITPA | ENSSSCP00000029207 | ENSSSCP00000054471 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.909 |
ENPP3 | MOCS1 | ENSSSCP00000029207 | ENSSSCP00000001730 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. | Molybdenum cofactor synthesis 1. | 0.805 |
ENPP3 | NUDT2 | ENSSSCP00000029207 | ENSSSCP00000011711 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis. | 0.928 |
ENPP3 | PDE10A | ENSSSCP00000029207 | ENSSSCP00000052616 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. | Phosphodiesterase. | 0.963 |
ENPP3 | PDE6A | ENSSSCP00000029207 | ENSSSCP00000015367 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. | Phosphodiesterase. | 0.890 |
ENPP3 | PKLR | ENSSSCP00000029207 | ENSSSCP00000036804 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.902 |
ENPP3 | PKM | ENSSSCP00000029207 | ENSSSCP00000051975 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. | Multifunctional fusion protein; Belongs to the pyruvate kinase family. | 0.902 |
ENPP3 | PLBD1 | ENSSSCP00000029207 | ENSSSCP00000051408 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. | Heat-stable enterotoxin receptor; Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.963 |
GUCA2B | PLBD1 | ENSSSCP00000004292 | ENSSSCP00000051408 | Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity); Belongs to the guanylin family. | Heat-stable enterotoxin receptor; Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.979 |
ITPA | ENPP1 | ENSSSCP00000054471 | ENSSSCP00000039332 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | Ectonucleotide pyrophosphatase/phosphodiesterase 1. | 0.909 |