node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A287A642_PIG | A0A287B199_PIG | ENSSSCP00000039333 | ENSSSCP00000049875 | MHC_I-like_Ag-recog domain-containing protein. | Ig-like domain-containing protein. | 0.425 |
A0A287A642_PIG | HCST | ENSSSCP00000039333 | ENSSSCP00000052528 | MHC_I-like_Ag-recog domain-containing protein. | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] | 0.586 |
A0A287A642_PIG | K7GSB8_PIG | ENSSSCP00000039333 | ENSSSCP00000030799 | MHC_I-like_Ag-recog domain-containing protein. | Ig-like domain-containing protein. | 0.425 |
A0A287A642_PIG | KLRK1 | ENSSSCP00000039333 | ENSSSCP00000034632 | MHC_I-like_Ag-recog domain-containing protein. | NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] | 0.968 |
A0A287A642_PIG | LOC100521998 | ENSSSCP00000039333 | ENSSSCP00000004427 | MHC_I-like_Ag-recog domain-containing protein. | MHC_I-like_Ag-recog domain-containing protein. | 0.405 |
A0A287A642_PIG | TYROBP | ENSSSCP00000039333 | ENSSSCP00000003143 | MHC_I-like_Ag-recog domain-containing protein. | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] | 0.469 |
A0A287A642_PIG | ULBP1 | ENSSSCP00000039333 | ENSSSCP00000004433 | MHC_I-like_Ag-recog domain-containing protein. | UL16-binding protein 1 isoform 1. | 0.491 |
A0A287B199_PIG | A0A287A642_PIG | ENSSSCP00000049875 | ENSSSCP00000039333 | Ig-like domain-containing protein. | MHC_I-like_Ag-recog domain-containing protein. | 0.425 |
A0A287B199_PIG | HCST | ENSSSCP00000049875 | ENSSSCP00000052528 | Ig-like domain-containing protein. | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] | 0.616 |
A0A287B199_PIG | K7GSB8_PIG | ENSSSCP00000049875 | ENSSSCP00000030799 | Ig-like domain-containing protein. | Ig-like domain-containing protein. | 0.408 |
A0A287B199_PIG | KLRK1 | ENSSSCP00000049875 | ENSSSCP00000034632 | Ig-like domain-containing protein. | NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] | 0.858 |
A0A287B199_PIG | LOC100521998 | ENSSSCP00000049875 | ENSSSCP00000004427 | Ig-like domain-containing protein. | MHC_I-like_Ag-recog domain-containing protein. | 0.425 |
A0A287B199_PIG | ULBP1 | ENSSSCP00000049875 | ENSSSCP00000004433 | Ig-like domain-containing protein. | UL16-binding protein 1 isoform 1. | 0.603 |
FCGR3A | HCST | ENSSSCP00000050675 | ENSSSCP00000052528 | Low affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] | 0.601 |
FCGR3A | KLRD1 | ENSSSCP00000050675 | ENSSSCP00000074449 | Low affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. | Killer cell lectin like receptor D1. | 0.534 |
FCGR3A | KLRK1 | ENSSSCP00000050675 | ENSSSCP00000034632 | Low affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. | NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] | 0.827 |
FCGR3A | TYROBP | ENSSSCP00000050675 | ENSSSCP00000003143 | Low affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] | 0.811 |
FCGR3A | ULBP1 | ENSSSCP00000050675 | ENSSSCP00000004433 | Low affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. | UL16-binding protein 1 isoform 1. | 0.557 |
HCST | A0A287A642_PIG | ENSSSCP00000052528 | ENSSSCP00000039333 | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] | MHC_I-like_Ag-recog domain-containing protein. | 0.586 |
HCST | A0A287B199_PIG | ENSSSCP00000052528 | ENSSSCP00000049875 | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] | Ig-like domain-containing protein. | 0.616 |