node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP2B1 | NFAT5 | ENSSSCP00000019788 | ENSSSCP00000029262 | AP complex subunit beta. | Nuclear factor of activated T cells 5. | 0.485 |
AP2B1 | REN | ENSSSCP00000019788 | ENSSSCP00000045910 | AP complex subunit beta. | Renin preproprotein; Belongs to the peptidase A1 family. | 0.517 |
CREB1 | EGR1 | ENSSSCP00000035901 | ENSSSCP00000015247 | Cyclic AMP-responsive element-binding protein 1 isoform B. | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | 0.627 |
CREB1 | FOS | ENSSSCP00000035901 | ENSSSCP00000070926 | Cyclic AMP-responsive element-binding protein 1 isoform B. | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] | 0.745 |
CREB1 | FOSB | ENSSSCP00000035901 | ENSSSCP00000060383 | Cyclic AMP-responsive element-binding protein 1 isoform B. | FosB proto-oncogene, AP-1 transcription factor subunit. | 0.695 |
CREB1 | NFAT5 | ENSSSCP00000035901 | ENSSSCP00000029262 | Cyclic AMP-responsive element-binding protein 1 isoform B. | Nuclear factor of activated T cells 5. | 0.683 |
EGR1 | CREB1 | ENSSSCP00000015247 | ENSSSCP00000035901 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Cyclic AMP-responsive element-binding protein 1 isoform B. | 0.627 |
EGR1 | FOS | ENSSSCP00000015247 | ENSSSCP00000070926 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] | 0.961 |
EGR1 | FOSB | ENSSSCP00000015247 | ENSSSCP00000060383 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | FosB proto-oncogene, AP-1 transcription factor subunit. | 0.893 |
EGR1 | NFAT5 | ENSSSCP00000015247 | ENSSSCP00000029262 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Nuclear factor of activated T cells 5. | 0.555 |
FOS | CREB1 | ENSSSCP00000070926 | ENSSSCP00000035901 | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] | Cyclic AMP-responsive element-binding protein 1 isoform B. | 0.745 |
FOS | EGR1 | ENSSSCP00000070926 | ENSSSCP00000015247 | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | 0.961 |
FOS | FOSB | ENSSSCP00000070926 | ENSSSCP00000060383 | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] | FosB proto-oncogene, AP-1 transcription factor subunit. | 0.994 |
FOS | NFAT5 | ENSSSCP00000070926 | ENSSSCP00000029262 | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] | Nuclear factor of activated T cells 5. | 0.722 |
FOSB | CREB1 | ENSSSCP00000060383 | ENSSSCP00000035901 | FosB proto-oncogene, AP-1 transcription factor subunit. | Cyclic AMP-responsive element-binding protein 1 isoform B. | 0.695 |
FOSB | EGR1 | ENSSSCP00000060383 | ENSSSCP00000015247 | FosB proto-oncogene, AP-1 transcription factor subunit. | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | 0.893 |
FOSB | FOS | ENSSSCP00000060383 | ENSSSCP00000070926 | FosB proto-oncogene, AP-1 transcription factor subunit. | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] | 0.994 |
FOSB | NFAT5 | ENSSSCP00000060383 | ENSSSCP00000029262 | FosB proto-oncogene, AP-1 transcription factor subunit. | Nuclear factor of activated T cells 5. | 0.700 |
GATA4 | NFAT5 | ENSSSCP00000027951 | ENSSSCP00000029262 | Transcription factor GATA-4 isoform 2. | Nuclear factor of activated T cells 5. | 0.515 |
MAPKBP1 | NFAT5 | ENSSSCP00000005108 | ENSSSCP00000029262 | Mitogen-activated protein kinase binding protein 1. | Nuclear factor of activated T cells 5. | 0.491 |