node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CES1 | CES1-2 | ENSSSCP00000040296 | ENSSSCP00000003044 | Liver carboxylesterase; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Active towards triacylglycerides containing short-chain fatty acids from C2 to C6, and 1(3)-monoacylglycerols containing fatty acids from C2 to C12. Inactive on long-chain triacylglycerols and diacylglycerol. Hydrolyzes aromatic and alkyl esters and vitamin A acetate. The hydrolysis rate depends upon the amino acid promoiety and the esterification site of the prodrug. Aromatic promoieties are favored, highest rates are observed with phenylalanyl progdrugs, hydrolysis [...] | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.803 |
CES1 | CTSA | ENSSSCP00000040296 | ENSSSCP00000071302 | Liver carboxylesterase; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Active towards triacylglycerides containing short-chain fatty acids from C2 to C6, and 1(3)-monoacylglycerols containing fatty acids from C2 to C12. Inactive on long-chain triacylglycerols and diacylglycerol. Hydrolyzes aromatic and alkyl esters and vitamin A acetate. The hydrolysis rate depends upon the amino acid promoiety and the esterification site of the prodrug. Aromatic promoieties are favored, highest rates are observed with phenylalanyl progdrugs, hydrolysis [...] | Carboxypeptidase; Belongs to the peptidase S10 family. | 0.524 |
CES1 | SLC14A2 | ENSSSCP00000040296 | ENSSSCP00000004845 | Liver carboxylesterase; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Active towards triacylglycerides containing short-chain fatty acids from C2 to C6, and 1(3)-monoacylglycerols containing fatty acids from C2 to C12. Inactive on long-chain triacylglycerols and diacylglycerol. Hydrolyzes aromatic and alkyl esters and vitamin A acetate. The hydrolysis rate depends upon the amino acid promoiety and the esterification site of the prodrug. Aromatic promoieties are favored, highest rates are observed with phenylalanyl progdrugs, hydrolysis [...] | Solute carrier family 14 member 2. | 0.550 |
CES1 | UPB1 | ENSSSCP00000040296 | ENSSSCP00000010733 | Liver carboxylesterase; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Active towards triacylglycerides containing short-chain fatty acids from C2 to C6, and 1(3)-monoacylglycerols containing fatty acids from C2 to C12. Inactive on long-chain triacylglycerols and diacylglycerol. Hydrolyzes aromatic and alkyl esters and vitamin A acetate. The hydrolysis rate depends upon the amino acid promoiety and the esterification site of the prodrug. Aromatic promoieties are favored, highest rates are observed with phenylalanyl progdrugs, hydrolysis [...] | Beta-ureidopropionase 1. | 0.512 |
CES1-2 | CES1 | ENSSSCP00000003044 | ENSSSCP00000040296 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Liver carboxylesterase; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Active towards triacylglycerides containing short-chain fatty acids from C2 to C6, and 1(3)-monoacylglycerols containing fatty acids from C2 to C12. Inactive on long-chain triacylglycerols and diacylglycerol. Hydrolyzes aromatic and alkyl esters and vitamin A acetate. The hydrolysis rate depends upon the amino acid promoiety and the esterification site of the prodrug. Aromatic promoieties are favored, highest rates are observed with phenylalanyl progdrugs, hydrolysis [...] | 0.803 |
CES1-2 | CTSA | ENSSSCP00000003044 | ENSSSCP00000071302 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Carboxypeptidase; Belongs to the peptidase S10 family. | 0.687 |
CES1-2 | GUK1 | ENSSSCP00000003044 | ENSSSCP00000035398 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. | 0.494 |
CES1-2 | HINT1 | ENSSSCP00000003044 | ENSSSCP00000015173 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Histidine triad nucleotide binding protein 1. | 0.584 |
CES1-2 | LAC_PIG | ENSSSCP00000003044 | ENSSSCP00000058189 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Ig lambda chain C region. | 0.751 |
CES1-2 | NEU2 | ENSSSCP00000003044 | ENSSSCP00000017266 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Neuraminidase 2. | 0.510 |
CES1-2 | PDIA5 | ENSSSCP00000003044 | ENSSSCP00000012642 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Protein disulfide isomerase family A member 5. | 0.568 |
CES1-2 | SLC14A2 | ENSSSCP00000003044 | ENSSSCP00000004845 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Solute carrier family 14 member 2. | 0.550 |
CES1-2 | SLC22A8 | ENSSSCP00000003044 | ENSSSCP00000033698 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Solute carrier family 22 member 8; Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.438 |
CES1-2 | UPB1 | ENSSSCP00000003044 | ENSSSCP00000010733 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Beta-ureidopropionase 1. | 0.512 |
CTSA | CES1 | ENSSSCP00000071302 | ENSSSCP00000040296 | Carboxypeptidase; Belongs to the peptidase S10 family. | Liver carboxylesterase; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Active towards triacylglycerides containing short-chain fatty acids from C2 to C6, and 1(3)-monoacylglycerols containing fatty acids from C2 to C12. Inactive on long-chain triacylglycerols and diacylglycerol. Hydrolyzes aromatic and alkyl esters and vitamin A acetate. The hydrolysis rate depends upon the amino acid promoiety and the esterification site of the prodrug. Aromatic promoieties are favored, highest rates are observed with phenylalanyl progdrugs, hydrolysis [...] | 0.524 |
CTSA | CES1-2 | ENSSSCP00000071302 | ENSSSCP00000003044 | Carboxypeptidase; Belongs to the peptidase S10 family. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.687 |
CTSA | GUK1 | ENSSSCP00000071302 | ENSSSCP00000035398 | Carboxypeptidase; Belongs to the peptidase S10 family. | Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. | 0.631 |
CTSA | HINT1 | ENSSSCP00000071302 | ENSSSCP00000015173 | Carboxypeptidase; Belongs to the peptidase S10 family. | Histidine triad nucleotide binding protein 1. | 0.709 |
CTSA | NEU2 | ENSSSCP00000071302 | ENSSSCP00000017266 | Carboxypeptidase; Belongs to the peptidase S10 family. | Neuraminidase 2. | 0.639 |
GUK1 | CES1-2 | ENSSSCP00000035398 | ENSSSCP00000003044 | Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.494 |