node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AASDH | CYP2A19 | ENSSSCP00000036252 | ENSSSCP00000003243 | Aminoadipate-semialdehyde dehydrogenase. | Cytochorme P450 2A19; Belongs to the cytochrome P450 family. | 0.519 |
AASDH | CYP2C36 | ENSSSCP00000036252 | ENSSSCP00000057853 | Aminoadipate-semialdehyde dehydrogenase. | Cytochrome P450 2C42; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.519 |
AASDH | CYP2D25 | ENSSSCP00000036252 | ENSSSCP00000000051 | Aminoadipate-semialdehyde dehydrogenase. | Vitamin D(3) 25-hydroxylase; Catalyzes the first step in the metabolic activation of vitamin D(3) into 1-alpha,25-dihydroxyvitamin D(3), its active, hormonal form. | 0.519 |
AASDH | CYP2E1 | ENSSSCP00000036252 | ENSSSCP00000069570 | Aminoadipate-semialdehyde dehydrogenase. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.519 |
AASDH | CYP3A22 | ENSSSCP00000036252 | ENSSSCP00000022617 | Aminoadipate-semialdehyde dehydrogenase. | Cytochrome P450 3A29; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.545 |
AASDH | CYP4A21 | ENSSSCP00000036252 | ENSSSCP00000061734 | Aminoadipate-semialdehyde dehydrogenase. | Cytochrome P450 4A24; Belongs to the cytochrome P450 family. | 0.542 |
CYP2A19 | AASDH | ENSSSCP00000003243 | ENSSSCP00000036252 | Cytochorme P450 2A19; Belongs to the cytochrome P450 family. | Aminoadipate-semialdehyde dehydrogenase. | 0.519 |
CYP2A19 | CYP2E1 | ENSSSCP00000003243 | ENSSSCP00000069570 | Cytochorme P450 2A19; Belongs to the cytochrome P450 family. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.925 |
CYP2A19 | CYP3A22 | ENSSSCP00000003243 | ENSSSCP00000022617 | Cytochorme P450 2A19; Belongs to the cytochrome P450 family. | Cytochrome P450 3A29; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.588 |
CYP2A19 | CYP4A21 | ENSSSCP00000003243 | ENSSSCP00000061734 | Cytochorme P450 2A19; Belongs to the cytochrome P450 family. | Cytochrome P450 4A24; Belongs to the cytochrome P450 family. | 0.568 |
CYP2C36 | AASDH | ENSSSCP00000057853 | ENSSSCP00000036252 | Cytochrome P450 2C42; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Aminoadipate-semialdehyde dehydrogenase. | 0.519 |
CYP2C36 | CYP3A22 | ENSSSCP00000057853 | ENSSSCP00000022617 | Cytochrome P450 2C42; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Cytochrome P450 3A29; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.957 |
CYP2C36 | CYP4A21 | ENSSSCP00000057853 | ENSSSCP00000061734 | Cytochrome P450 2C42; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Cytochrome P450 4A24; Belongs to the cytochrome P450 family. | 0.562 |
CYP2D25 | AASDH | ENSSSCP00000000051 | ENSSSCP00000036252 | Vitamin D(3) 25-hydroxylase; Catalyzes the first step in the metabolic activation of vitamin D(3) into 1-alpha,25-dihydroxyvitamin D(3), its active, hormonal form. | Aminoadipate-semialdehyde dehydrogenase. | 0.519 |
CYP2D25 | CYP3A22 | ENSSSCP00000000051 | ENSSSCP00000022617 | Vitamin D(3) 25-hydroxylase; Catalyzes the first step in the metabolic activation of vitamin D(3) into 1-alpha,25-dihydroxyvitamin D(3), its active, hormonal form. | Cytochrome P450 3A29; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.647 |
CYP2D25 | CYP4A21 | ENSSSCP00000000051 | ENSSSCP00000061734 | Vitamin D(3) 25-hydroxylase; Catalyzes the first step in the metabolic activation of vitamin D(3) into 1-alpha,25-dihydroxyvitamin D(3), its active, hormonal form. | Cytochrome P450 4A24; Belongs to the cytochrome P450 family. | 0.604 |
CYP2E1 | AASDH | ENSSSCP00000069570 | ENSSSCP00000036252 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | Aminoadipate-semialdehyde dehydrogenase. | 0.519 |
CYP2E1 | CYP2A19 | ENSSSCP00000069570 | ENSSSCP00000003243 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | Cytochorme P450 2A19; Belongs to the cytochrome P450 family. | 0.925 |
CYP2E1 | CYP3A22 | ENSSSCP00000069570 | ENSSSCP00000022617 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | Cytochrome P450 3A29; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.956 |
CYP2E1 | CYP4A21 | ENSSSCP00000069570 | ENSSSCP00000061734 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | Cytochrome P450 4A24; Belongs to the cytochrome P450 family. | 0.553 |