node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD63 | RAB27A | ENSSSCP00000029639 | ENSSSCP00000041641 | Tetraspanin. | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | 0.809 |
DCT | MYO5A | ENSSSCP00000010135 | ENSSSCP00000004979 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Unconventional myosin-Va isoform X3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.626 |
DCT | RAB27A | ENSSSCP00000010135 | ENSSSCP00000041641 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | 0.717 |
DCT | TYR | ENSSSCP00000010135 | ENSSSCP00000028210 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Tyrosinase. | 0.734 |
MYO5A | DCT | ENSSSCP00000004979 | ENSSSCP00000010135 | Unconventional myosin-Va isoform X3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | 0.626 |
MYO5A | MYRIP | ENSSSCP00000004979 | ENSSSCP00000074015 | Unconventional myosin-Va isoform X3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Myosin VIIA and Rab interacting protein. | 0.706 |
MYO5A | RAB27A | ENSSSCP00000004979 | ENSSSCP00000041641 | Unconventional myosin-Va isoform X3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | 0.971 |
MYO5A | SYTL3 | ENSSSCP00000004979 | ENSSSCP00000004384 | Unconventional myosin-Va isoform X3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Synaptotagmin like 3. | 0.516 |
MYO5A | SYTL4 | ENSSSCP00000004979 | ENSSSCP00000013279 | Unconventional myosin-Va isoform X3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Synaptotagmin like 4. | 0.519 |
MYO5A | SYTL5 | ENSSSCP00000004979 | ENSSSCP00000059505 | Unconventional myosin-Va isoform X3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Synaptotagmin-like protein 5 isoform X1. | 0.515 |
MYO5A | TYR | ENSSSCP00000004979 | ENSSSCP00000028210 | Unconventional myosin-Va isoform X3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Tyrosinase. | 0.813 |
MYRIP | MYO5A | ENSSSCP00000074015 | ENSSSCP00000004979 | Myosin VIIA and Rab interacting protein. | Unconventional myosin-Va isoform X3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.706 |
MYRIP | RAB27A | ENSSSCP00000074015 | ENSSSCP00000041641 | Myosin VIIA and Rab interacting protein. | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | 0.877 |
MYRIP | SYTL1 | ENSSSCP00000074015 | ENSSSCP00000060401 | Myosin VIIA and Rab interacting protein. | Synaptotagmin like 1. | 0.672 |
MYRIP | SYTL2 | ENSSSCP00000074015 | ENSSSCP00000015831 | Myosin VIIA and Rab interacting protein. | Synaptotagmin like 2. | 0.487 |
RAB27A | CD63 | ENSSSCP00000041641 | ENSSSCP00000029639 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | Tetraspanin. | 0.809 |
RAB27A | DCT | ENSSSCP00000041641 | ENSSSCP00000010135 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | 0.717 |
RAB27A | MYO5A | ENSSSCP00000041641 | ENSSSCP00000004979 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | Unconventional myosin-Va isoform X3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.971 |
RAB27A | MYRIP | ENSSSCP00000041641 | ENSSSCP00000074015 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | Myosin VIIA and Rab interacting protein. | 0.877 |
RAB27A | SYTL1 | ENSSSCP00000041641 | ENSSSCP00000060401 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | Synaptotagmin like 1. | 0.818 |