close STRING Database User Survey
Please help us improve further — take a moment to fill our brief user survey.
 
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CRNNUncharacterized protein; Cornulin (603 aa)    
Predicted Functional Partners:
BLOC1S1
Biogenesis of lysosomal organelles complex 1 subunit 1
      
 0.827
KPRP
Keratinocyte proline-rich protein
   
  
 0.714
C10orf10
Chromosome 10 open reading frame 10
      
 0.683
KRT78
Keratin, type ii cytoskeletal 71; Belongs to the intermediate filament family
   
  
 0.588
SAMD14
Sterile alpha motif domain containing 14
      
 0.576
ADAMTS20
Uncharacterized protein; ADAM metallopeptidase with thrombospondin type 1 motif, 20
      
 0.574
GOT2
Aspartate aminotransferase, mitochondrial precursor; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity)
      
 0.561
GOT1
Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- [...]
      
 0.561
CASP14
Caspase 14, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family
   
  
 0.560
PMEL
Melanocyte protein pmel; Premelanosome protein
      
 0.531
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (12%) [HD]