STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ID1Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein; Uncharacterized protein (154 aa)    
Predicted Functional Partners:
ETS1
Uncharacterized protein; V-ets avian erythroblastosis virus E26 oncogene homolog 1
   
 0.921
THBS1
Uncharacterized protein; Sus scrofa thrombospondin 1 (THBS1), mRNA
   
 
 0.882
ID4
DNA-binding protein inhibitor ID-4; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity)
   
0.879
TCF4
Transcription factor 4
   
 
 0.872
ID3
Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
   
  
 0.862
ID2
DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...]
   
 
0.819
TCF3
Transcription factor 3
   
 
 0.813
RAP1A
annotation not available
     
  0.800
SCNN1A
Uncharacterized protein; Sodium channel, non-voltage-gated 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family
      
 0.725
SPIC
Uncharacterized protein; Spi-C transcription factor (Spi-1/PU.1 related)
    
 
 0.666
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, Sus scrofa, pig, pigs, swine, wild boar
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