node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A287AAC1_PIG | DCT | ENSSSCP00000040952 | ENSSSCP00000010135 | Uncharacterized protein. | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | 0.661 |
A0A287AAC1_PIG | EDN3 | ENSSSCP00000040952 | ENSSSCP00000066984 | Uncharacterized protein. | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. | 0.571 |
A0A287AAC1_PIG | MC1R | ENSSSCP00000040952 | ENSSSCP00000027395 | Uncharacterized protein. | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a role in the regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis; Belongs to the G-protein coupled receptor 1 family. | 0.659 |
A0A287AAC1_PIG | MITF | ENSSSCP00000040952 | ENSSSCP00000051180 | Uncharacterized protein. | Microphthalmia-associated transcription factor isoform 1. | 0.557 |
A0A287AAC1_PIG | SLC45A2 | ENSSSCP00000040952 | ENSSSCP00000070836 | Uncharacterized protein. | Membrane-associated transporter protein; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity); Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. | 0.443 |
A0A287AAC1_PIG | TYR | ENSSSCP00000040952 | ENSSSCP00000028210 | Uncharacterized protein. | Tyrosinase. | 0.748 |
A0A287AAC1_PIG | TYRP1 | ENSSSCP00000040952 | ENSSSCP00000005583 | Uncharacterized protein. | 5,6-dihydroxyindole-2-carboxylic acid oxidase. | 0.648 |
DCT | A0A287AAC1_PIG | ENSSSCP00000010135 | ENSSSCP00000040952 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Uncharacterized protein. | 0.661 |
DCT | EDN3 | ENSSSCP00000010135 | ENSSSCP00000066984 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. | 0.699 |
DCT | MC1R | ENSSSCP00000010135 | ENSSSCP00000027395 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a role in the regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis; Belongs to the G-protein coupled receptor 1 family. | 0.689 |
DCT | MITF | ENSSSCP00000010135 | ENSSSCP00000051180 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Microphthalmia-associated transcription factor isoform 1. | 0.837 |
DCT | MLANA | ENSSSCP00000010135 | ENSSSCP00000005596 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Melanoma antigen recognized by T-cells 1. | 0.785 |
DCT | RAB27A | ENSSSCP00000010135 | ENSSSCP00000041641 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | 0.717 |
DCT | SLC45A2 | ENSSSCP00000010135 | ENSSSCP00000070836 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Membrane-associated transporter protein; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity); Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. | 0.701 |
DCT | SOX10 | ENSSSCP00000010135 | ENSSSCP00000035739 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). | 0.758 |
DCT | TYR | ENSSSCP00000010135 | ENSSSCP00000028210 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Tyrosinase. | 0.734 |
DCT | TYRP1 | ENSSSCP00000010135 | ENSSSCP00000005583 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | 5,6-dihydroxyindole-2-carboxylic acid oxidase. | 0.937 |
EDN3 | A0A287AAC1_PIG | ENSSSCP00000066984 | ENSSSCP00000040952 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. | Uncharacterized protein. | 0.571 |
EDN3 | DCT | ENSSSCP00000066984 | ENSSSCP00000010135 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | 0.699 |
EDN3 | MC1R | ENSSSCP00000066984 | ENSSSCP00000027395 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a role in the regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis; Belongs to the G-protein coupled receptor 1 family. | 0.538 |