node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGER | CLDN18 | ENSSSCP00000001544 | ENSSSCP00000012426 | Advanced glycosylation end-product specific receptor. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.463 |
AGER | SCGB1A1 | ENSSSCP00000001544 | ENSSSCP00000013890 | Advanced glycosylation end-product specific receptor. | Secretoglobin family 1A member 1. | 0.695 |
AGER | SFTPA1 | ENSSSCP00000001544 | ENSSSCP00000067056 | Advanced glycosylation end-product specific receptor. | Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages; Belongs to the SFTPA family. | 0.804 |
AGER | SFTPB | ENSSSCP00000001544 | ENSSSCP00000049863 | Advanced glycosylation end-product specific receptor. | Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. | 0.811 |
AGER | SFTPC | ENSSSCP00000001544 | ENSSSCP00000010269 | Advanced glycosylation end-product specific receptor. | Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. | 0.866 |
AGER | SFTPD | ENSSSCP00000001544 | ENSSSCP00000058499 | Advanced glycosylation end-product specific receptor. | Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family. | 0.700 |
C1RL | SFTPD | ENSSSCP00000000716 | ENSSSCP00000058499 | Complement C1r subcomponent like; Belongs to the peptidase S1 family. | Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family. | 0.591 |
CALR | SFTPD | ENSSSCP00000014615 | ENSSSCP00000058499 | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis; Belongs to the calreticulin family. | Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family. | 0.564 |
CLDN18 | AGER | ENSSSCP00000012426 | ENSSSCP00000001544 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Advanced glycosylation end-product specific receptor. | 0.463 |
CLDN18 | SFTPA1 | ENSSSCP00000012426 | ENSSSCP00000067056 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages; Belongs to the SFTPA family. | 0.438 |
CLDN18 | SFTPB | ENSSSCP00000012426 | ENSSSCP00000049863 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. | 0.535 |
CLDN18 | SFTPC | ENSSSCP00000012426 | ENSSSCP00000010269 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. | 0.692 |
CLDN18 | SFTPD | ENSSSCP00000012426 | ENSSSCP00000058499 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family. | 0.610 |
LPCAT1 | SFTPB | ENSSSCP00000018133 | ENSSSCP00000049863 | Lysophosphatidylcholine acyltransferase 1. | Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. | 0.651 |
LPCAT1 | SFTPC | ENSSSCP00000018133 | ENSSSCP00000010269 | Lysophosphatidylcholine acyltransferase 1. | Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. | 0.517 |
LPCAT1 | SFTPD | ENSSSCP00000018133 | ENSSSCP00000058499 | Lysophosphatidylcholine acyltransferase 1. | Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family. | 0.574 |
PPIE | SFTPD | ENSSSCP00000031786 | ENSSSCP00000058499 | Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. | Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family. | 0.614 |
SCGB1A1 | AGER | ENSSSCP00000013890 | ENSSSCP00000001544 | Secretoglobin family 1A member 1. | Advanced glycosylation end-product specific receptor. | 0.695 |
SCGB1A1 | SFTPA1 | ENSSSCP00000013890 | ENSSSCP00000067056 | Secretoglobin family 1A member 1. | Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages; Belongs to the SFTPA family. | 0.810 |
SCGB1A1 | SFTPB | ENSSSCP00000013890 | ENSSSCP00000049863 | Secretoglobin family 1A member 1. | Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. | 0.837 |