node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH18A1 | CPS1 | ENSSSCP00000011182 | ENSSSCP00000051055 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Carbamoyl-phosphate synthase 1. | 0.770 |
ALDH18A1 | GLS | ENSSSCP00000011182 | ENSSSCP00000055263 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glutaminase. | 0.960 |
ALDH18A1 | GLS2 | ENSSSCP00000011182 | ENSSSCP00000000427 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glutaminase 2. | 0.963 |
ALDH18A1 | GLUD1 | ENSSSCP00000011182 | ENSSSCP00000011056 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). | 0.977 |
ALDH18A1 | GLUL | ENSSSCP00000011182 | ENSSSCP00000042620 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating [...] | 0.914 |
ALDH18A1 | GOT1 | ENSSSCP00000011182 | ENSSSCP00000011226 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.447 |
ALDH18A1 | GOT2 | ENSSSCP00000011182 | ENSSSCP00000055842 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). | 0.471 |
ALDH18A1 | GPT2 | ENSSSCP00000011182 | ENSSSCP00000061787 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glutamic--pyruvic transaminase 2. | 0.617 |
ALDH18A1 | IDH1 | ENSSSCP00000011182 | ENSSSCP00000022058 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.583 |
ALDH18A1 | IDH2 | ENSSSCP00000011182 | ENSSSCP00000036736 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex. | 0.583 |
CPS1 | ALDH18A1 | ENSSSCP00000051055 | ENSSSCP00000011182 | Carbamoyl-phosphate synthase 1. | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.770 |
CPS1 | GLS | ENSSSCP00000051055 | ENSSSCP00000055263 | Carbamoyl-phosphate synthase 1. | Glutaminase. | 0.907 |
CPS1 | GLS2 | ENSSSCP00000051055 | ENSSSCP00000000427 | Carbamoyl-phosphate synthase 1. | Glutaminase 2. | 0.917 |
CPS1 | GLUD1 | ENSSSCP00000051055 | ENSSSCP00000011056 | Carbamoyl-phosphate synthase 1. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). | 0.974 |
CPS1 | GLUL | ENSSSCP00000051055 | ENSSSCP00000042620 | Carbamoyl-phosphate synthase 1. | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating [...] | 0.965 |
CPS1 | GPT2 | ENSSSCP00000051055 | ENSSSCP00000061787 | Carbamoyl-phosphate synthase 1. | Glutamic--pyruvic transaminase 2. | 0.473 |
GLS | ALDH18A1 | ENSSSCP00000055263 | ENSSSCP00000011182 | Glutaminase. | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.960 |
GLS | CPS1 | ENSSSCP00000055263 | ENSSSCP00000051055 | Glutaminase. | Carbamoyl-phosphate synthase 1. | 0.907 |
GLS | GLS2 | ENSSSCP00000055263 | ENSSSCP00000000427 | Glutaminase. | Glutaminase 2. | 0.903 |
GLS | GLUD1 | ENSSSCP00000055263 | ENSSSCP00000011056 | Glutaminase. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). | 0.982 |