STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CTSLCathepsin L1; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family (334 aa)    
Predicted Functional Partners:
ENSSSCG00000029421
Collagen type XV alpha 1 chain
    
 0.921
COL18A1
annotation not available
    
 0.919
MMP7
Matrix metallopeptidase 7 (matrilysin, uterine); Belongs to the peptidase M10A family
     
 0.914
MMP-13
Matrix metalloproteinase; Belongs to the peptidase M10A family
     
 0.911
ENSSSCG00000005380
Uncharacterized protein
    
 0.910
TLR9
Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity)
   
 
 0.909
SLA-DRB1
Sus scrofa MHC class II histocompatibility antigen SLA-DRB1 (SLA-DRB1), mRNA
   
 0.904
SLA-DQB1
SLA class II histocompatibility antigen, DQ haplotype C beta chain; Sus scrofa SLA-DQ beta1 domain (SLA-DQB1), mRNA
   
 0.904
SLA-DRA
Major histocompatibility complex, class II, DR alpha; Sus scrofa MHC class II DR-alpha (SLA-DRA), mRNA; Belongs to the MHC class II family
     
 0.901
ENSSSCG00000001458
Uncharacterized protein; Belongs to the MHC class II family
     
  0.900
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, Sus scrofa, pig, pigs, swine, wild boar
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