node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD14 | CSF1R | ENSSSCP00000015286 | ENSSSCP00000064716 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Colony stimulating factor 1 receptor. | 0.573 |
CD14 | SPI1 | ENSSSCP00000015286 | ENSSSCP00000073995 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA- 3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). | 0.912 |
CSF1R | CD14 | ENSSSCP00000064716 | ENSSSCP00000015286 | Colony stimulating factor 1 receptor. | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | 0.573 |
CSF1R | FCGR1A | ENSSSCP00000064716 | ENSSSCP00000054981 | Colony stimulating factor 1 receptor. | Uncharacterized protein. | 0.416 |
CSF1R | RUNX1 | ENSSSCP00000064716 | ENSSSCP00000041677 | Colony stimulating factor 1 receptor. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.947 |
CSF1R | SPI1 | ENSSSCP00000064716 | ENSSSCP00000073995 | Colony stimulating factor 1 receptor. | Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA- 3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). | 0.959 |
ELK4 | ETS2 | ENSSSCP00000033955 | ENSSSCP00000038432 | ETS domain-containing protein Elk-4 isoform a. | Protein C-ets-2; Transcription factor; Belongs to the ETS family. | 0.907 |
ELK4 | SPI1 | ENSSSCP00000033955 | ENSSSCP00000073995 | ETS domain-containing protein Elk-4 isoform a. | Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA- 3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). | 0.905 |
ETS2 | ELK4 | ENSSSCP00000038432 | ENSSSCP00000033955 | Protein C-ets-2; Transcription factor; Belongs to the ETS family. | ETS domain-containing protein Elk-4 isoform a. | 0.907 |
ETS2 | RUNX1 | ENSSSCP00000038432 | ENSSSCP00000041677 | Protein C-ets-2; Transcription factor; Belongs to the ETS family. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.645 |
ETS2 | SPI1 | ENSSSCP00000038432 | ENSSSCP00000073995 | Protein C-ets-2; Transcription factor; Belongs to the ETS family. | Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA- 3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). | 0.911 |
FCGR1A | CSF1R | ENSSSCP00000054981 | ENSSSCP00000064716 | Uncharacterized protein. | Colony stimulating factor 1 receptor. | 0.416 |
FCGR1A | SPI1 | ENSSSCP00000054981 | ENSSSCP00000073995 | Uncharacterized protein. | Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA- 3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). | 0.921 |
FLT3 | RARA | ENSSSCP00000028275 | ENSSSCP00000035518 | Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Retinoic acid receptor alpha isoform X1. | 0.417 |
FLT3 | RUNX1 | ENSSSCP00000028275 | ENSSSCP00000041677 | Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.585 |
FLT3 | SPI1 | ENSSSCP00000028275 | ENSSSCP00000073995 | Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA- 3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). | 0.923 |
PML | RARA | ENSSSCP00000002091 | ENSSSCP00000035518 | Promyelocytic leukemia. | Retinoic acid receptor alpha isoform X1. | 0.963 |
PML | RUNX1 | ENSSSCP00000002091 | ENSSSCP00000041677 | Promyelocytic leukemia. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.915 |
PML | SPI1 | ENSSSCP00000002091 | ENSSSCP00000073995 | Promyelocytic leukemia. | Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA- 3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). | 0.906 |
RARA | FLT3 | ENSSSCP00000035518 | ENSSSCP00000028275 | Retinoic acid receptor alpha isoform X1. | Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.417 |