STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPI1Transcription factor pu.1; Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA- 3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity) (270 aa)    
Predicted Functional Partners:
IRF8
Interferon regulatory factor 8
   
 
 0.955
CSF1R
Macrophage colony-stimulating factor 1 receptor isoform x1; Colony stimulating factor 1 receptor
   
 
 0.948
ENSSSCP00000012832
Runt-related transcription factor 1; Runt-related transcription factor; CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters
   
 0.921
FLT3
Receptor-type tyrosine-protein kinase flt3 isoform x2; Fms-related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily
   
 
 0.900
ITGAM
Integrin alpha-m isoform x2; Uncharacterized protein; Integrin, alpha M (complement component 3 receptor 3 subunit)
   
 
 0.884
GATA1
Erythroid transcription factor; GATA 1 protein; Uncharacterized protein
   
 
 0.883
RARA
Retinoic acid receptor alpha isoform x2; Retinoic acid receptor, alpha
   
 0.878
CEBPA
CCAAT/enhancer binding protein (C/EBP), alpha
   
 
 0.875
TBP
Transcription initiation factor tfiid tata-box-binding protein; TATA box binding protein
    
 0.874
JUN
Transcription factor ap-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter
    
 
 0.854
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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