STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKR1A1Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (By similarity). Functions as a detox [...] (365 aa)    
Predicted Functional Partners:
ALDH3B2
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
   
 0.961
ALDH3B1
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
   
 0.960
ALDH3A1
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
   
 0.957
ALDH1B1
Aldehyde dehydrogenase 1 family member B1; Belongs to the aldehyde dehydrogenase family.
   
 0.949
ALDH3A2
Aldehyde dehydrogenase 3 family member A2; Belongs to the aldehyde dehydrogenase family.
   
 0.931
ALDH2
Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid.
   
 0.926
ALDH7A1
Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family.
   
 0.924
ALDH9A1
4-trimethylaminobutyraldehyde dehydrogenase; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency.
   
 0.923
ADH5
S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
   
 0.920
ADH4
Alcohol dehydrogenase 4 isoform 2.
   
 0.919
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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