node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTL7A | PTGR1 | ENSSSCP00000005834 | ENSSSCP00000039006 | Actin like 7A; Belongs to the actin family. | Prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. | 0.726 |
BPIFB2 | CLDN6 | ENSSSCP00000071573 | ENSSSCP00000072421 | BPI2 domain-containing protein. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.725 |
BPIFB2 | FREM1 | ENSSSCP00000071573 | ENSSSCP00000055655 | BPI2 domain-containing protein. | FRAS1 related extracellular matrix 1. | 0.780 |
BPIFB2 | PTGR1 | ENSSSCP00000071573 | ENSSSCP00000039006 | BPI2 domain-containing protein. | Prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. | 0.737 |
BPIFB2 | SCARA3 | ENSSSCP00000071573 | ENSSSCP00000049071 | BPI2 domain-containing protein. | Scavenger receptor class A member 3 isoform X1. | 0.777 |
BPIFB2 | YLPM1 | ENSSSCP00000071573 | ENSSSCP00000002569 | BPI2 domain-containing protein. | YLP motif-containing protein 1. | 0.772 |
CLDN6 | BPIFB2 | ENSSSCP00000072421 | ENSSSCP00000071573 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | BPI2 domain-containing protein. | 0.725 |
CLDN6 | FREM1 | ENSSSCP00000072421 | ENSSSCP00000055655 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | FRAS1 related extracellular matrix 1. | 0.727 |
CLDN6 | PTGR1 | ENSSSCP00000072421 | ENSSSCP00000039006 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. | 0.553 |
CLDN6 | SCARA3 | ENSSSCP00000072421 | ENSSSCP00000049071 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Scavenger receptor class A member 3 isoform X1. | 0.720 |
CLDN6 | YLPM1 | ENSSSCP00000072421 | ENSSSCP00000002569 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | YLP motif-containing protein 1. | 0.609 |
EPHX1 | MGAT4B | ENSSSCP00000011571 | ENSSSCP00000072380 | Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B. | 0.559 |
EPHX1 | PTGR1 | ENSSSCP00000011571 | ENSSSCP00000039006 | Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. | Prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. | 0.594 |
ERRFI1 | PTGR1 | ENSSSCP00000039820 | ENSSSCP00000039006 | ERBB receptor feedback inhibitor 1. | Prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. | 0.608 |
FREM1 | BPIFB2 | ENSSSCP00000055655 | ENSSSCP00000071573 | FRAS1 related extracellular matrix 1. | BPI2 domain-containing protein. | 0.780 |
FREM1 | CLDN6 | ENSSSCP00000055655 | ENSSSCP00000072421 | FRAS1 related extracellular matrix 1. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.727 |
FREM1 | PTGR1 | ENSSSCP00000055655 | ENSSSCP00000039006 | FRAS1 related extracellular matrix 1. | Prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. | 0.669 |
FREM1 | SCARA3 | ENSSSCP00000055655 | ENSSSCP00000049071 | FRAS1 related extracellular matrix 1. | Scavenger receptor class A member 3 isoform X1. | 0.779 |
FREM1 | YLPM1 | ENSSSCP00000055655 | ENSSSCP00000002569 | FRAS1 related extracellular matrix 1. | YLP motif-containing protein 1. | 0.721 |
MGAT4B | EPHX1 | ENSSSCP00000072380 | ENSSSCP00000011571 | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B. | Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. | 0.559 |