node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANXA10 | TFF2 | ENSSSCP00000022848 | ENSSSCP00000025323 | Annexin A10. | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. | 0.584 |
CLPS | TFF2 | ENSSSCP00000001686 | ENSSSCP00000025323 | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. | 0.566 |
GAST | TCN1 | ENSSSCP00000022312 | ENSSSCP00000037395 | Big gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. | Transcobalamin-1; Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach (By similarity). Binds to cobalamin and to cobalamin analogs such as cobinamide; Belongs to the eukaryotic cobalamin transport proteins family. | 0.617 |
GAST | TFF2 | ENSSSCP00000022312 | ENSSSCP00000025323 | Big gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. | 0.670 |
GKN1 | GKN2 | ENSSSCP00000021568 | ENSSSCP00000061086 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | BRICHOS domain-containing protein. | 0.636 |
GKN1 | TFF2 | ENSSSCP00000021568 | ENSSSCP00000025323 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. | 0.539 |
GKN2 | GKN1 | ENSSSCP00000061086 | ENSSSCP00000021568 | BRICHOS domain-containing protein. | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | 0.636 |
GKN2 | TFF2 | ENSSSCP00000061086 | ENSSSCP00000025323 | BRICHOS domain-containing protein. | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. | 0.548 |
GKN3 | TFF2 | ENSSSCP00000040669 | ENSSSCP00000025323 | Gastrokine-3; May inhibit gastric epithelial cell proliferation. Belongs to the gastrokine family. | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. | 0.547 |
MUC2 | MUC5AC | ENSSSCP00000067835 | ENSSSCP00000045466 | Uncharacterized protein. | Uncharacterized protein. | 0.553 |
MUC2 | TFF2 | ENSSSCP00000067835 | ENSSSCP00000025323 | Uncharacterized protein. | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. | 0.580 |
MUC5AC | MUC2 | ENSSSCP00000045466 | ENSSSCP00000067835 | Uncharacterized protein. | Uncharacterized protein. | 0.553 |
MUC5AC | TFF2 | ENSSSCP00000045466 | ENSSSCP00000025323 | Uncharacterized protein. | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. | 0.671 |
REG4 | TFF2 | ENSSSCP00000041356 | ENSSSCP00000025323 | Regenerating islet derived family member 4 variant 2. | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. | 0.636 |
TCN1 | GAST | ENSSSCP00000037395 | ENSSSCP00000022312 | Transcobalamin-1; Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach (By similarity). Binds to cobalamin and to cobalamin analogs such as cobinamide; Belongs to the eukaryotic cobalamin transport proteins family. | Big gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. | 0.617 |
TCN1 | TFF2 | ENSSSCP00000037395 | ENSSSCP00000025323 | Transcobalamin-1; Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach (By similarity). Binds to cobalamin and to cobalamin analogs such as cobinamide; Belongs to the eukaryotic cobalamin transport proteins family. | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. | 0.590 |
TFF2 | ANXA10 | ENSSSCP00000025323 | ENSSSCP00000022848 | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. | Annexin A10. | 0.584 |
TFF2 | CLPS | ENSSSCP00000025323 | ENSSSCP00000001686 | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | 0.566 |
TFF2 | GAST | ENSSSCP00000025323 | ENSSSCP00000022312 | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. | Big gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. | 0.670 |
TFF2 | GKN1 | ENSSSCP00000025323 | ENSSSCP00000021568 | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | 0.539 |