node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRDT | PRM2 | ENSSSCP00000041214 | ENSSSCP00000024012 | Bromodomain testis associated. | Protamine-2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | 0.530 |
BRDT | TNP1 | ENSSSCP00000041214 | ENSSSCP00000017139 | Bromodomain testis associated. | Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. | 0.616 |
BRDT | TNP2 | ENSSSCP00000041214 | ENSSSCP00000025815 | Bromodomain testis associated. | Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. | 0.614 |
DMRT1 | PRM2 | ENSSSCP00000067348 | ENSSSCP00000024012 | Doublesex- and mab-3-related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and prom [...] | Protamine-2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | 0.442 |
DMRT1 | TNP1 | ENSSSCP00000067348 | ENSSSCP00000017139 | Doublesex- and mab-3-related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and prom [...] | Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. | 0.613 |
DMRT1 | TNP2 | ENSSSCP00000067348 | ENSSSCP00000025815 | Doublesex- and mab-3-related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and prom [...] | Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. | 0.577 |
ELOB | TNP2 | ENSSSCP00000070702 | ENSSSCP00000025815 | Elongin B. | Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. | 0.565 |
GPR149 | PRM2 | ENSSSCP00000042052 | ENSSSCP00000024012 | G protein-coupled receptor 149. | Protamine-2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | 0.669 |
GPR149 | TNP2 | ENSSSCP00000042052 | ENSSSCP00000025815 | G protein-coupled receptor 149. | Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. | 0.721 |
IQCF1 | KLHL10 | ENSSSCP00000020205 | ENSSSCP00000054606 | IQ motif containing F1. | Kelch like family member 10. | 0.808 |
IQCF1 | PRM2 | ENSSSCP00000020205 | ENSSSCP00000024012 | IQ motif containing F1. | Protamine-2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | 0.567 |
IQCF1 | TNP1 | ENSSSCP00000020205 | ENSSSCP00000017139 | IQ motif containing F1. | Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. | 0.576 |
IQCF1 | TNP2 | ENSSSCP00000020205 | ENSSSCP00000025815 | IQ motif containing F1. | Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. | 0.685 |
KLHL10 | IQCF1 | ENSSSCP00000054606 | ENSSSCP00000020205 | Kelch like family member 10. | IQ motif containing F1. | 0.808 |
KLHL10 | PRM2 | ENSSSCP00000054606 | ENSSSCP00000024012 | Kelch like family member 10. | Protamine-2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | 0.645 |
KLHL10 | TNP2 | ENSSSCP00000054606 | ENSSSCP00000025815 | Kelch like family member 10. | Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. | 0.608 |
LOC100519930 | TNP1 | ENSSSCP00000017987 | ENSSSCP00000017139 | Histone domain-containing protein; Belongs to the histone H2B family. | Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. | 0.533 |
LOC100519930 | TNP2 | ENSSSCP00000017987 | ENSSSCP00000025815 | Histone domain-containing protein; Belongs to the histone H2B family. | Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. | 0.685 |
PRM2 | BRDT | ENSSSCP00000024012 | ENSSSCP00000041214 | Protamine-2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | Bromodomain testis associated. | 0.530 |
PRM2 | DMRT1 | ENSSSCP00000024012 | ENSSSCP00000067348 | Protamine-2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | Doublesex- and mab-3-related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and prom [...] | 0.442 |