node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABRAXAS1 | BABAM1 | ENSSSCP00000009847 | ENSSSCP00000033853 | Abraxas 1, BRCA1 A complex subunit. | BRISC and BRCA1 A complex member 1. | 0.999 |
ABRAXAS1 | BABAM2 | ENSSSCP00000009847 | ENSSSCP00000054528 | Abraxas 1, BRCA1 A complex subunit. | BRISC and BRCA1 A complex member 2. | 0.996 |
ABRAXAS1 | BARD1 | ENSSSCP00000009847 | ENSSSCP00000069422 | Abraxas 1, BRCA1 A complex subunit. | BRCA1 associated RING domain 1. | 0.988 |
ABRAXAS1 | BRCA1 | ENSSSCP00000009847 | ENSSSCP00000034439 | Abraxas 1, BRCA1 A complex subunit. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.990 |
ABRAXAS1 | BRCC3 | ENSSSCP00000009847 | ENSSSCP00000067829 | Abraxas 1, BRCA1 A complex subunit. | BRCA1/BRCA2-containing complex subunit 3. | 0.997 |
ABRAXAS1 | NBN | ENSSSCP00000009847 | ENSSSCP00000048770 | Abraxas 1, BRCA1 A complex subunit. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.728 |
ABRAXAS1 | RPS27A | ENSSSCP00000009847 | ENSSSCP00000049299 | Abraxas 1, BRCA1 A complex subunit. | Ubiquitin-like domain-containing protein. | 0.512 |
ABRAXAS1 | UBC | ENSSSCP00000009847 | ENSSSCP00000062692 | Abraxas 1, BRCA1 A complex subunit. | Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] | 0.531 |
ABRAXAS1 | UIMC1 | ENSSSCP00000009847 | ENSSSCP00000026135 | Abraxas 1, BRCA1 A complex subunit. | BRCA1-A complex subunit RAP80; Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. M [...] | 0.995 |
BABAM1 | ABRAXAS1 | ENSSSCP00000033853 | ENSSSCP00000009847 | BRISC and BRCA1 A complex member 1. | Abraxas 1, BRCA1 A complex subunit. | 0.999 |
BABAM1 | BABAM2 | ENSSSCP00000033853 | ENSSSCP00000054528 | BRISC and BRCA1 A complex member 1. | BRISC and BRCA1 A complex member 2. | 0.999 |
BABAM1 | BARD1 | ENSSSCP00000033853 | ENSSSCP00000069422 | BRISC and BRCA1 A complex member 1. | BRCA1 associated RING domain 1. | 0.910 |
BABAM1 | BRCA1 | ENSSSCP00000033853 | ENSSSCP00000034439 | BRISC and BRCA1 A complex member 1. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.992 |
BABAM1 | BRCC3 | ENSSSCP00000033853 | ENSSSCP00000067829 | BRISC and BRCA1 A complex member 1. | BRCA1/BRCA2-containing complex subunit 3. | 0.999 |
BABAM1 | NBN | ENSSSCP00000033853 | ENSSSCP00000048770 | BRISC and BRCA1 A complex member 1. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.611 |
BABAM1 | RPS27A | ENSSSCP00000033853 | ENSSSCP00000049299 | BRISC and BRCA1 A complex member 1. | Ubiquitin-like domain-containing protein. | 0.517 |
BABAM1 | UBC | ENSSSCP00000033853 | ENSSSCP00000062692 | BRISC and BRCA1 A complex member 1. | Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] | 0.507 |
BABAM1 | UIMC1 | ENSSSCP00000033853 | ENSSSCP00000026135 | BRISC and BRCA1 A complex member 1. | BRCA1-A complex subunit RAP80; Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. M [...] | 0.994 |
BABAM2 | ABRAXAS1 | ENSSSCP00000054528 | ENSSSCP00000009847 | BRISC and BRCA1 A complex member 2. | Abraxas 1, BRCA1 A complex subunit. | 0.996 |
BABAM2 | BABAM1 | ENSSSCP00000054528 | ENSSSCP00000033853 | BRISC and BRCA1 A complex member 2. | BRISC and BRCA1 A complex member 1. | 0.999 |