node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC73 | ERCC6L | ENSSSCP00000051617 | ENSSSCP00000022977 | Coiled-coil domain containing 73. | ERCC excision repair 6 like, spindle assembly checkpoint helicase. | 0.756 |
CCDC73 | GPER1 | ENSSSCP00000051617 | ENSSSCP00000027235 | Coiled-coil domain containing 73. | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.646 |
CCDC73 | PTPDC1 | ENSSSCP00000051617 | ENSSSCP00000041309 | Coiled-coil domain containing 73. | Protein tyrosine phosphatase domain containing 1. | 0.761 |
CYP19A1 | ESR1 | ENSSSCP00000046988 | ENSSSCP00000030835 | Aromatase 3; Catalyzes the formation of aromatic C18 estrogens from C19 androgens; Belongs to the cytochrome P450 family. | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.907 |
CYP19A1 | ESR2 | ENSSSCP00000046988 | ENSSSCP00000005491 | Aromatase 3; Catalyzes the formation of aromatic C18 estrogens from C19 androgens; Belongs to the cytochrome P450 family. | Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. | 0.831 |
CYP19A1 | GPER1 | ENSSSCP00000046988 | ENSSSCP00000027235 | Aromatase 3; Catalyzes the formation of aromatic C18 estrogens from C19 androgens; Belongs to the cytochrome P450 family. | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.656 |
ERCC6L | CCDC73 | ENSSSCP00000022977 | ENSSSCP00000051617 | ERCC excision repair 6 like, spindle assembly checkpoint helicase. | Coiled-coil domain containing 73. | 0.756 |
ERCC6L | GPER1 | ENSSSCP00000022977 | ENSSSCP00000027235 | ERCC excision repair 6 like, spindle assembly checkpoint helicase. | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.646 |
ERCC6L | PTPDC1 | ENSSSCP00000022977 | ENSSSCP00000041309 | ERCC excision repair 6 like, spindle assembly checkpoint helicase. | Protein tyrosine phosphatase domain containing 1. | 0.763 |
ESR1 | CYP19A1 | ENSSSCP00000030835 | ENSSSCP00000046988 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Aromatase 3; Catalyzes the formation of aromatic C18 estrogens from C19 androgens; Belongs to the cytochrome P450 family. | 0.907 |
ESR1 | ESR2 | ENSSSCP00000030835 | ENSSSCP00000005491 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. | 0.974 |
ESR1 | GNB1 | ENSSSCP00000030835 | ENSSSCP00000048402 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | G protein subunit beta 1. | 0.506 |
ESR1 | GPER1 | ENSSSCP00000030835 | ENSSSCP00000027235 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.868 |
ESR1 | PTK2 | ENSSSCP00000030835 | ENSSSCP00000057598 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.496 |
ESR1 | SRC | ENSSSCP00000030835 | ENSSSCP00000029882 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Tyrosine-protein kinase. | 0.996 |
ESR2 | CYP19A1 | ENSSSCP00000005491 | ENSSSCP00000046988 | Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. | Aromatase 3; Catalyzes the formation of aromatic C18 estrogens from C19 androgens; Belongs to the cytochrome P450 family. | 0.831 |
ESR2 | ESR1 | ENSSSCP00000005491 | ENSSSCP00000030835 | Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.974 |
ESR2 | GNB1 | ENSSSCP00000005491 | ENSSSCP00000048402 | Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. | G protein subunit beta 1. | 0.506 |
ESR2 | GPER1 | ENSSSCP00000005491 | ENSSSCP00000027235 | Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.924 |
ESR2 | SRC | ENSSSCP00000005491 | ENSSSCP00000029882 | Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. | Tyrosine-protein kinase. | 0.954 |