node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHUK | IKBKB | ENSSSCP00000011239 | ENSSSCP00000007492 | Protein kinase domain-containing protein. | Inhibitor of kappa light chain gene enhancer in B cells, kinase beta. | 0.999 |
CHUK | IKBKG | ENSSSCP00000011239 | ENSSSCP00000048392 | Protein kinase domain-containing protein. | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] | 0.999 |
CHUK | IRAK4 | ENSSSCP00000011239 | ENSSSCP00000000849 | Protein kinase domain-containing protein. | Protein kinase domain-containing protein. | 0.966 |
CHUK | MAP3K7 | ENSSSCP00000011239 | ENSSSCP00000057259 | Protein kinase domain-containing protein. | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | 0.972 |
CHUK | NFKBIA | ENSSSCP00000011239 | ENSSSCP00000002133 | Protein kinase domain-containing protein. | NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. | 0.999 |
CHUK | RIPK1 | ENSSSCP00000011239 | ENSSSCP00000059220 | Protein kinase domain-containing protein. | Receptor interacting serine/threonine kinase 1. | 0.956 |
CHUK | TAB1 | ENSSSCP00000011239 | ENSSSCP00000028647 | Protein kinase domain-containing protein. | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. | 0.964 |
CHUK | TAB2 | ENSSSCP00000011239 | ENSSSCP00000036269 | Protein kinase domain-containing protein. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. | 0.975 |
CHUK | TAB3 | ENSSSCP00000011239 | ENSSSCP00000060766 | Protein kinase domain-containing protein. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. | 0.960 |
CHUK | TRAF6 | ENSSSCP00000011239 | ENSSSCP00000034114 | Protein kinase domain-containing protein. | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] | 0.991 |
IKBKB | CHUK | ENSSSCP00000007492 | ENSSSCP00000011239 | Inhibitor of kappa light chain gene enhancer in B cells, kinase beta. | Protein kinase domain-containing protein. | 0.999 |
IKBKB | IKBKG | ENSSSCP00000007492 | ENSSSCP00000048392 | Inhibitor of kappa light chain gene enhancer in B cells, kinase beta. | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] | 0.999 |
IKBKB | IRAK4 | ENSSSCP00000007492 | ENSSSCP00000000849 | Inhibitor of kappa light chain gene enhancer in B cells, kinase beta. | Protein kinase domain-containing protein. | 0.930 |
IKBKB | MAP3K7 | ENSSSCP00000007492 | ENSSSCP00000057259 | Inhibitor of kappa light chain gene enhancer in B cells, kinase beta. | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | 0.976 |
IKBKB | NFKBIA | ENSSSCP00000007492 | ENSSSCP00000002133 | Inhibitor of kappa light chain gene enhancer in B cells, kinase beta. | NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. | 0.997 |
IKBKB | RIPK1 | ENSSSCP00000007492 | ENSSSCP00000059220 | Inhibitor of kappa light chain gene enhancer in B cells, kinase beta. | Receptor interacting serine/threonine kinase 1. | 0.938 |
IKBKB | TAB1 | ENSSSCP00000007492 | ENSSSCP00000028647 | Inhibitor of kappa light chain gene enhancer in B cells, kinase beta. | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. | 0.963 |
IKBKB | TAB2 | ENSSSCP00000007492 | ENSSSCP00000036269 | Inhibitor of kappa light chain gene enhancer in B cells, kinase beta. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. | 0.964 |
IKBKB | TAB3 | ENSSSCP00000007492 | ENSSSCP00000060766 | Inhibitor of kappa light chain gene enhancer in B cells, kinase beta. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. | 0.949 |
IKBKB | TRAF6 | ENSSSCP00000007492 | ENSSSCP00000034114 | Inhibitor of kappa light chain gene enhancer in B cells, kinase beta. | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] | 0.973 |