STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
apt1Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (189 aa)    
Predicted Functional Partners:
guaB
GMP synthase, subunit B; Catalyzes the synthesis of GMP from XMP.
  
 0.985
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase, putative; Protein involved in IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity.
  
 0.973
purB
Protein involved in adenylosuccinate lyase activity; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.972
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
  
 
 0.956
guaA
GMP synthase, subunit A; Catalyzes the synthesis of GMP from XMP.
 
 
 0.945
ade
Protein involved in adenine deaminase activity and adenine salvage; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
    
 0.943
surE
5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.932
MCON_2743
HAD-superfamily hydrolase, subfamily IA, variant 1.
  
 
 0.919
MCON_1268
Conserved hypothetical protein.
 
  
  0.914
MCON_1091
Conserved domain protein.
     
 0.912
Your Current Organism:
Methanothrix soehngenii
NCBI taxonomy Id: 990316
Other names: M. soehngenii GP6, Methanosaeta concilii DSM 3671, Methanosaeta concilii GP6, Methanothrix soehngenii DSM 3671, Methanothrix soehngenii GP6
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