STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1497 aa)    
Predicted Functional Partners:
GRIN1
Glutamate ionotropic receptor NMDA type subunit 1.
   
 0.995
DLG4
Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.
    
 0.989
GRIN2D
Glutamate ionotropic receptor NMDA type subunit 2D.
     
0.975
GRIN2A
Glutamate ionotropic receptor NMDA type subunit 2A.
   
0.971
GRIN2C
Glutamate ionotropic receptor NMDA type subunit 2C.
     
0.962
ENSBTAP00000068368
CaM_bdg_C0 domain-containing protein.
   
 0.947
NOS1
Nitric oxide synthase; Produces nitric oxide (NO).
    
 0.936
PDYN
Alpha-neoendorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Leumorphin has a typical opiod activity and may have anti- apoptotic effect.
   
 
 0.931
CALML4
Calmodulin-like protein 4; Belongs to the calmodulin family.
    
 0.927
PRKACB
cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, and differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these [...]
    
 0.924
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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