node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSBTAP00000066030 | GNRH1 | ENSBTAP00000066030 | ENSBTAP00000000188 | Uncharacterized protein. | Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. | 0.865 |
ENSBTAP00000066030 | GNRHR | ENSBTAP00000066030 | ENSBTAP00000000559 | Uncharacterized protein. | Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.817 |
ENSBTAP00000066030 | TAC3 | ENSBTAP00000066030 | ENSBTAP00000029067 | Uncharacterized protein. | Neurokinin-B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity); Belongs to the tachykinin family. | 0.515 |
FSHB | FSHR | ENSBTAP00000014462 | ENSBTAP00000048971 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | 0.998 |
FSHB | GNRH1 | ENSBTAP00000014462 | ENSBTAP00000000188 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. | 0.757 |
FSHB | GNRHR | ENSBTAP00000014462 | ENSBTAP00000000559 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.913 |
FSHB | KISS1R | ENSBTAP00000014462 | ENSBTAP00000060740 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | KISS1 receptor. | 0.475 |
FSHB | TAC3 | ENSBTAP00000014462 | ENSBTAP00000029067 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | Neurokinin-B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity); Belongs to the tachykinin family. | 0.464 |
FSHB | TSHB | ENSBTAP00000014462 | ENSBTAP00000008264 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. | 0.447 |
FSHR | FSHB | ENSBTAP00000048971 | ENSBTAP00000014462 | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | 0.998 |
FSHR | GNAS | ENSBTAP00000048971 | ENSBTAP00000023246 | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | Neuroendocrine secretory protein 55; Belongs to the NESP55 family. | 0.902 |
FSHR | GNRH1 | ENSBTAP00000048971 | ENSBTAP00000000188 | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. | 0.642 |
FSHR | GNRHR | ENSBTAP00000048971 | ENSBTAP00000000559 | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.702 |
FSHR | TSHB | ENSBTAP00000048971 | ENSBTAP00000008264 | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. | 0.876 |
GNA11 | GNAQ | ENSBTAP00000050620 | ENSBTAP00000016160 | Guanine nucleotide-binding protein subunit alpha-11; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | G protein subunit alpha q. | 0.936 |
GNA11 | GNRHR | ENSBTAP00000050620 | ENSBTAP00000000559 | Guanine nucleotide-binding protein subunit alpha-11; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.920 |
GNA11 | KISS1R | ENSBTAP00000050620 | ENSBTAP00000060740 | Guanine nucleotide-binding protein subunit alpha-11; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | KISS1 receptor. | 0.918 |
GNAQ | GNA11 | ENSBTAP00000016160 | ENSBTAP00000050620 | G protein subunit alpha q. | Guanine nucleotide-binding protein subunit alpha-11; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | 0.936 |
GNAQ | GNRHR | ENSBTAP00000016160 | ENSBTAP00000000559 | G protein subunit alpha q. | Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.918 |
GNAQ | KISS1R | ENSBTAP00000016160 | ENSBTAP00000060740 | G protein subunit alpha q. | KISS1 receptor. | 0.918 |